Improved synthesis of γ-nitro-α-amino ester and acid derivatives

被引：8
|
作者：
Ballini, R
Balsamini, C
Bartoccini, F
Gianotti, M
Martinelli, C
Savoretti, N
机构：
[1] Univ Camerino, Dipartimento Sci Chim, I-62032 Camerino, MC, Italy
[2] Univ Urbino, Ist Chim Farmaceut, I-61029 Urbino, PU, Italy
来源：
SYNTHESIS-STUTTGART | 2005年 / 02期
关键词：
microwave-assisted synthesis; alpha-amino acids; methyl N-(diphenylmethylene)-2,3-didehydroalaninate; nitroalkanes;
D O I：
10.1055/s-2004-834927
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A useful microwave-assisted synthesis of gamma-nitro-alpha-amino esters and corresponding acids, under mild conditions and without solvent, is described. The desired products were obtained via Michael addition from methyl N-(diphenylmethylene)-2,3-didehydroalaninate and commercially available nitroalkanes.
引用
收藏
页码：296 / 300
页数：5
相关论文
共 50 条
  • [1] The nitro- and amino-derivatives of m-hydroxybenzoic acid.
    Froelicher, V
    Cohen, JB
    JOURNAL OF THE CHEMICAL SOCIETY, 1921, 119 : 1425 - 1432
  • [2] Nitro-, Azo-, and Amino Derivatives of Ebselen: Synthesis, Structure, and Cytoprotective Effects
    Singh, Vijay P.
    Poon, Jia-fei
    Yan, Jiajie
    Lu, Xi
    Ott, Marjam Karlsson
    Butcher, Ray J.
    Gates, Paul J.
    Engman, Lars
    JOURNAL OF ORGANIC CHEMISTRY, 2017, 82 (01): : 313 - 321
  • [3] The nitro- and amino-derivatives of 4-phenylglyoxaline.
    Grant, RL
    Pyman, FL
    JOURNAL OF THE CHEMICAL SOCIETY, 1921, 119 : 1893 - 1903
  • [4] The nitro- and amino formazyl
    Bamberger, E
    Padova, R
    Ormerod, E
    JUSTUS LIEBIGS ANNALEN DER CHEMIE, 1926, 446 : 260 - 307
  • [5] About the effect of sabatine acid on the aniline nitro- isomatic ester
    Semper, L
    Lichtenstadt, L
    JUSTUS LIEBIGS ANNALEN DER CHEMIE, 1913, 400 (1/3): : 302 - 332
  • [6] Nitro- and Amino-ethoxylutidine.
    Collie, JN
    Bishop, G
    JOURNAL OF THE CHEMICAL SOCIETY, 1925, 127 : 962 - 964
  • [7] NITRO- AND AMINO-IMIDAZOLESULPHONAMIDES
    FISHER, MH
    NICHOLSON, WH
    STUART, RS
    CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1961, 39 (03): : 501 - &
  • [8] Synthesis of nitro- and aminoindoles
    Yamashkin S.A.
    Yurovskaya M.A.
    Chemistry of Heterocyclic Compounds, 1999, 35 (12) : 1426 - 1432
  • [9] NITRO- AND AMINO-PHENYLOSOTRIAZOLES
    KHADEM, HE
    MESHREKI, MH
    NATURE, 1962, 194 (4826) : 373 - &
  • [10] The Synthesis and Evaluation of Arctigenin Amino Acid Ester Derivatives
    Cai, En-bo
    Yang, Li-min
    Jia, Cai-xia
    Zhang, Wei-yuan
    Zhao, Yan
    Li, Wei
    Song, Xing-zhuo
    Zheng, Man-ling
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2016, 64 (10) : 1466 - 1473
12345