Evaluation of in-vivo Hepatoprotective activity of methanolic extract of Mentha spicata and Capsicum annum leaves in albino rats

This research work was performed to evaluate the hepatoprotective activity of methanolic extracts of Mentha spicata and Capsicum annum leaves in comparison with silymarin in paracetamol induced hepatotoxicity in albino rats. Six groups each comprising of six albino rats were treated orally for 15 days. Group-I served as negative control, received 100mg/kg paracetamol, Group-II received 200 mg/kg M. spicata + 100 mg/kg paracetamol, Group-III received 200mg/kg C. annum + 100 mg/kg paracetamol, Group VI received 100 mg/kg M. spicata and 100mg/kg C. annum, Group V received 100mg/kg silymarin, Group IV served as normal control and received 10% DMSO. Hepatoprotective effect was evaluated by comparing serum bilirubin, serum ALP, serum glutamate pyruvate transaminase or (ALAT), serum glutamate oxaloacetate transaminase or (ASAT), albumin, globulin and total protein and liver histopathology. Results were represented as mean +/- SEM. One-way ANOVA was done followed by post hoc Tukey's test with a highly significance level of P <0.001. All the evaluated extracts exhibited hepatoprotective potential as compared standard drug silymarin.