Clinical, histopathological and metabolic responses following exercise in Arabian horses with a history of exertional rhabdomyolysis

被引:11
|
作者
McKenzie, E. C. [1 ]
Eyrich, L. V. [1 ]
Payton, M. E. [2 ]
Valberg, S. J. [3 ,4 ]
机构
[1] Oregon State Univ, Dept Vet Clin Sci, Coll Vet Med, 227 Magruder Hall, Corvallis, OR 97331 USA
[2] Oklahoma State Univ, Dept Stat, 301B MSCS Bldg, Stillwater, OK 74078 USA
[3] Univ Minnesota, Dept Vet Populat Med, Coll Vet Med, 225 VMC,1365 Gartner Ave, St Paul, MN 55108 USA
[4] Michigan State Univ, McPhail Equine Performance Ctr, 736 Wilson Rd, E Lansing, MI 48824 USA
来源
VETERINARY JOURNAL | 2016年 / 216卷
关键词
Creatine kinase; Horse; Muscle biopsy; Myopathy; POLYSACCHARIDE STORAGE MYOPATHY; CREATINE-KINASE ACTIVITY; ENDURANCE HORSES; MUTATION; PERFORMANCE; PREVALENCE;
D O I
10.1016/j.tvjl.2016.08.011
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
A previous report suggests a substantial incidence of exertional rhabdomyolysis (ER) in Arabian horses performing endurance racing. This study compared formalin histopathology and clinical and metabolic responses to a standardised field exercise test (SET) between Arabians with and without ER. Arabian horses with (n = 10; age 15.4 +/- 5.6 years) and without (n = 9; 12.9 +/- 6.1 years) prior ER were stall-rested for 24-48 h, after which paired ER and control horses were fitted with a telemetric ECG and performed a 47 min submaximal SET. Plasma glucose, lactate, electrolyte and total protein concentrations and packed cell volume were measured before and immediately after exercise. Blood and percutaneous gluteal muscle samples were also obtained before and 3 h after exercise for measurement of plasma creatine kinase (CK) activity and muscle glycogen concentration, respectively. Histopathologic analysis of formalin-fixed pre exercise muscle sections was performed. Data were analyzed by ANOVA and non-parametric tests (P < 0.05). No horses displayed clinical signs of ER during exercise, and plasma CK increased similarly in ER and control Arabians. Muscle glycogen, heart rate, and remaining plasma variables did not differ between horses with ER and control horses. Horses with ER had more internalised nuclei in mature myofibers, more aggregates of cytoplasmic glycogen and desmin, and higher myopathic scores than control horses. Although many horses with ER had histopathologic evidence of chronic myopathy, muscle glycogen concentrations and metabolic exercise responses were normal. Results did not support a consistent metabolic myopathy or a glycogen storage disorder in Arabians with ER. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码:196 / 201
页数:6
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