Effect of Prostaglandin E1 on arteriosclerosis obliterans in diabetic patients

The aim of this study is to evaluate the effect of Prostaglandin E-1 on arteriosclerosis obliterans in diabetic patients. In the present study, it is clear that the continuous intravenous administration of PGE(1) at 120 mug/day for 3 weeks has significantly improved subjective symptoms evaluated by the visual analogue scale, such as, coldness, numbness and pain in the lower extremities. Moreover, the circulatory status in the lower extremities was evaluated using the cold stress test by the thermography. Thus, it is indicated that the continuous intravenous administration of PGE(1) should significantly improve the circulatory status as well as subjective symptoms. (arteriosclerosis obliterans, prostaglandin E-1,diabetic patients, cold stress test, visual analogue scale, thermography).