The importance of reducing heart rate in cardiovascular diseases: effects of Ivabradine

被引：0
|
作者：
Vizzardi, E. [1 ]
Bonadei, I. [1 ]
D'Aloia, A. [1 ]
Del Magro, F. [1 ]
Piovanelli, B. [1 ]
Bontempi, L. [1 ]
Curnis, A. [1 ]
Cas, L. Dei [1 ]
机构：
[1] Univ Study Brescia, Sect Cardiovasc Dis, Dept Expt & Appl Med, Brescia, Italy
来源：
MINERVA MEDICA | 2011年 / 102卷 / 05期
关键词：
Heart rate; Heart failure; Cardiovascular; diseases; ORTHOSTATIC TACHYCARDIA SYNDROME; INAPPROPRIATE SINUS TACHYCARDIA; CURRENT INHIBITOR IVABRADINE; I-F INHIBITOR; RATE REDUCTION; STABLE ANGINA; MYOCARDIAL-ISCHEMIA; DOUBLE-BLIND; ATHEROSCLEROSIS; DYSFUNCTION;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Heart rate is a major determinant of cardiac output, myocardial oxygen consumption and coronary blood flow under physiological and pathological conditions. Experimental and clinical data have demonstrated that heart rate reduction is the main mechanism for reducing ischemia, improving left ventricular function, decreasing the risk of plaque rupture and post myocardial infarction mortality. Nowadays betablockers are the best class of drugs that can lower heart rate in patients with cardiovascular diseases, but sometimes their use is limited by some contraindications. Ivabradine is a new drug that reduces the firing rate of pacemaker cells in the sinoatrial node through a different mechanism with respect to betablockers. The purpose of this review is to investigate the main trials that support Ivabradine adoption in clinical practice.
引用
收藏
页码：373 / 379
页数：7
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