Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24

被引:58
|
作者
Mai, M
Qian, CP
Yokomizo, A
Smith, DI
Liu, WG
机构
[1] Mayo Clin & Mayo Fdn, Dept Lab Med & Pathol, Div Expt Pathol, Rochester, MN 55905 USA
[2] Mayo Clin & Mayo Fdn, Dept Urol Res, Rochester, MN 55905 USA
关键词
D O I
10.1006/geno.1998.5650
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Conductin or Axil, an Axin homolog, plays an important role in the regulation of beta-catenin stability in the Wnt signaling pathway. To facilitate the molecular analysis of the human gene, we isolated the human homolog, AXIN2. The cDNA contains a 2529-bp open reading frame and encodes a putative protein of 843 amino acids. Compared with rat and mouse homologs, AXIN2 shows an overall 89% amino acid identity. Several functional domains in this protein are highly conserved including the GRS (95.9%), GSK-3 beta (96.3%), Dsh (98%), and beta-catenin (89.9%) domains. Radiation hybrid mapping localized the AXIN2 gene to human chromosome 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Human AXIN2 is thus a very strong candidate involved in multiple tumor types. (C) 1999 Academic Press.
引用
收藏
页码:341 / 344
页数:4
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