Potential beneficial and/or adverse effects of Capsicum annuum L. (cv. Fiesta) at two stage of ripening in CD-1 mice

被引：9

作者：

Morittu, Valeria Maria ^{[1
]}

Pero, Maria Elena ^{[2
]}

Musco, Nadia ^{[2
]}

Mastellone, Vincenzo ^{[2
]}

Tudisco, Raffaella ^{[2
]}

Provenzano, Eugenio ^{[3
]}

Britti, Domenico ^{[1
]}

Menichini, Francesco ^{[4
]}

Infascelli, Federico ^{[2
]}

Lombardi, Pietro ^{[2
]}

机构：

[1] Magna Graecia Univ Catanzaro, CIS Interdept Serv Ctr Vet Human & Anim Hlth, Catanzaro, Italy

[2] Univ Napoli Federico II, Dept Vet Med & Anim Prod, Naples, Italy

[3] AO Cosenza, Operat Unit Dermatol, Cosenza, Italy

[4] Univ Calabria, Dept Pharm Hlth & Nutr Sci, Arcavacata Di Rende, Italy

来源：

NATURAL PRODUCT RESEARCH | 2020年 / 34卷 / 11期

关键词：

Capsicum annuum; antioxidants; phytotherapy; red pepper; capsaicin; RED-PEPPER; CAPSAICIN; ANTIOXIDANT; FLAVONOIDS; TOXICITY;

D O I：

10.1080/14786419.2018.1525371

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Aim of the present study was to evaluate the potential beneficial and/or adverse effects of Capsicum annuum L. (cv. Fiesta) extracts at two stage of ripening (immature and mature), and at two dosages (low and high) by evaluation of biochemical profile and oxidative status in CD-1 mice. The extracts were daily administered to mice by oral gavage for 20 days. At the end of the trial, the animals were euthanatized and blood was collected. Evidence of liver damage (increase of AST, ALT and bilirubin) in the group receiving the higher dosage of immature peppers extract were observed. Even if no adverse effects were seen at the lower doses, also no signs of beneficial effects in term of health status, biochemical profile and oxidative status were detected. These results are in contrast with in vitro findings and raise doubts about the possible use of Capsicum annuum L. (cv. Fiesta) as a nutritional supplement.

引用

页码：1647 / 1651

页数：5

共 22 条

[21] Isolation of cDNAs differentially expressed in response to drought stress and characterization of the Ca-LEAL1 gene encoding a new family of atypical LEA-like protein homologue in hot pepper (Capsicum annuum L. cv. Pukang)
Park, JA
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Hong, CB
Kim, WT
PLANT SCIENCE, 2003, 165 (03) : 471 - 481
[22] Lack of tumor promoting effects of KCB-1, a recombinant human basic fibroblast growth factor, on two-stage skin carcinogenesis in female CD-1 (ICR) mice
Tanaka, H
Takesada, Y
Shibata, MA
Kawabe, M
Sano, M
Tamano, S
Sugimoto, H
Nakamura, T
Hagiwara, A
CANCER LETTERS, 1996, 105 (02) : 195 - 202

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