Increased expression of CD44 is associated with more aggressive behavior in clear cell renal cell carcinoma

被引：30
|
作者：
Zanjani, Leili Saeednejad [1 ]
Madjd, Zahra [1 ,2 ]
Abolhasani, Maryam [1 ,3 ]
Rasti, Arezoo [1 ]
Fodstad, Oystein [4 ,5 ]
Andersson, Yvonne [4 ]
Asgari, Mojgan [1 ,3 ]
机构：
[1] Iran Univ Med Sci, Oncopathol Res Ctr, Tehran, Iran
[2] Iran Univ Med Sci, Fac Adv Technol Med, Dept Mol Med, Tehran, Iran
[3] Iran Univ Med Sci, Hasheminejad Kidney Ctr, Tehran, Iran
[4] Oslo Univ Hosp, Norwegian Radium Hosp, Dept Tumor Biol, N-0424 Oslo, Norway
[5] Univ Oslo, Fac Med, Inst Clin Med, N-0310 Oslo, Norway
来源：
BIOMARKERS IN MEDICINE | 2018年 / 12卷 / 01期
关键词：
cancer stem cells; CD44; renal cell carcinoma; tissue microarray; CANCER STEM-CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; MICROSCOPIC VENOUS INVASION; INTERNATIONAL-SOCIETY; PROGNOSTIC VALUE; METASTASIS; MOLECULE; IDENTIFICATION; POPULATIONS; ACQUISITION;
D O I：
10.2217/bmm-2017-0142
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: Although CD44 has been suggested as a prognostic marker in renal cell carcinoma (RCC), the prognostic significance of this marker in three main subtypes of RCC is still unclear. Thus, the present study was conducted to evaluate the expression and prognostic significance of CD44 as a cancer stem cell marker in different histological subtypes of RCC. Methodology & results: CD44 expression was evaluated in 206 well-defined renal tumor samples using immunohistochemistry on tissue microarrays. Higher CD44 expression was associated with more aggressive behavior, tumor progression and worse prognosis in clear cell RCC (ccRCC) but not in papillary and chromophobe RCC subtypes. Discussion & conclusion: Cancer stem cell marker CD44 may be a promising target for cancer treatment only in ccRCC.
引用
收藏
页码：45 / 61
页数：17
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