A novel human leukocyte elastase inhibitor from duck egg white

被引：2
|
作者：
Valueva, TA
Kladnitskaya, GV
Mosolov, VV
机构：
来源：
IMMUNOPHARMACOLOGY | 1996年 / 32卷 / 1-3期
关键词：
duck ovomucoid; leukocyte elastase; serine proteinase;
D O I：
10.1016/0162-3109(95)00066-6
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A serine proteinase inhibitor (ovomucoid) has been isolated from duck egg white. The duck ovomucoid effectively inhibited HLE, PPE, chymotrypsin, and HCG in a 1:1 molar ratio, and trypsin in a 1:2 molar ratio. Inhibition of human plasmin and porcine pancreatic kallikrein was not observed. The ovomucoid shows equilibrium dissociation constants of 0.002; 2.4; 2.2; 6.1; and 18.0 nhl for HLE, PPE, chymotrypsin, trypsin, and HCG, respectively. The molecule of inhibitor can simultaneously bind two trypsin molecules and one molecule of elastase (or chymotrypsin).
引用
收藏
页码：108 / 110
页数：3
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