Pharmacogenetic profile and major depressive and/or bipolar disorder treatment: a retrospective, cross-sectional study

被引：8
|
作者：
Tonozzi, Theresa R. [1 ]
Braunstein, Glenn D. [1 ]
Kammesheidt, Anja [1 ]
Curran, Chris [2 ]
Golshan, Shahrokh [3 ]
Kelsoe, John [3 ]
机构：
[1] Pathway Genom, San Diego, CA 92121 USA
[2] Patients Like Me, Cambridge, MA 02142 USA
[3] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
来源：
PHARMACOGENOMICS | 2018年 / 19卷 / 15期
关键词：
antidepressant; antipsychotic; bipolar disorder; generalized anxiety disorder; major depressive disorder; mood stabilizer; pharmacogenetics; selective serotonin reuptake inhibitors; tricyclic antidepressants; STAR-ASTERISK-D; CARE; GUIDELINES; OUTCOMES; UTILITY; UPDATE; 2D6;
D O I：
10.2217/pgs-2018-0088
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aim: To compare pharmacogenetic test predictions with self-reported treatment experience and side effect tolerability among patients with depression taking psychotherapeutic medications. Methods: Subjects completed a survey recalling medication effectiveness and side effects and then underwent pharmacogenetic testing. Results: Our 15 gene pharmacogenetic panel predicted efficacy (p < 0.001) but did not predict side effect tolerability (p = 0.70) in a group of 352 patients. The pharmacogenetic panel and reported efficacy corresponded 60% of the time and medication tolerability agreed 71% of the time. Conclusion: Pharmacogenetic testing may be a useful adjunct to predict efficacy of medications used to treat depression.
引用
收藏
页码：1169 / 1179
页数：11
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