Intermediate filament structure: the bottom-up approach

被引：80

作者：

Chernyatina, Anastasia A. ^{[1
]}

Guzenko, Dmytro ^{[1
]}

Strelkov, Sergei V. ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Lab Biocrystallog, Dept Pharmaceut & Pharmacol Sci, Leuven, Belgium

来源：

CURRENT OPINION IN CELL BIOLOGY | 2015年 / 32卷

关键词：

HUMAN LAMIN; MOLECULAR ARCHITECTURE; SECONDARY STRUCTURE; CELL ARCHITECTURE; ATOMIC-STRUCTURE; GLOBULAR TAIL; VIMENTIN; DOMAIN; DIMER; 2B;

D O I：

10.1016/j.ceb.2014.12.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Intermediate filaments (IFs) result from a key cytoskeletal protein class in metazoan cells, but currently there is no consensus as to their three-dimensional architecture. IF proteins form elongated dimers based on the coiled-coil structure within their central 'rod' domain. Here we focus on the atomic structure of this elementary dimer, elucidated using Xray crystallography on multiple fragments and electron paramagnetic resonance experiments on spin-labelled vimentin samples. In line with conserved sequence features, the rod of all IF proteins is composed of three coiled-coil segments containing heptad and hendecad repeats and interconnected by linkers. In addition, the next assembly intermediate beyond the dimer, the tetramer, could be modelled. The impact of these structural results towards understanding the assembly mechanism is discussed.

引用

页码：65 / 72

页数：8

共 50 条

[31] Bottom-up approach for carbon nanotube interconnects
Li, J
Ye, Q
Cassell, A
Ng, HT
Stevens, R
Han, J
Meyyappan, M
APPLIED PHYSICS LETTERS, 2003, 82 (15) : 2491 - 2493
[32] Bottom-Up Approach to Energy Services Platform
McKeever, P.
Monti, A.
2016 IEEE INTERNATIONAL ENERGY CONFERENCE (ENERGYCON), 2016,
[33] Bottom-up approach to the Galactic Center excess
Izaguirre, Eder
Krnjaic, Gordan
Shuve, Brian
PHYSICAL REVIEW D, 2014, 90 (05):
[34] Improvement of the "Bottom-up" Approach in Value Engineering
Jiang, Zhi-wei
Yu, Hua-yan
Wang, Xue-song
PROCEEDINGS OF THE 22ND INTERNATIONAL CONFERENCE ON INDUSTRIAL ENGINEERING AND ENGINEERING MANAGEMENT: INNOVATION AND PRACTICE IN INDUSTRIAL ENGINEERING AND MANAGEMENT (VOL 2), 2016, : 461 - 468
[35] A "bottom-up" approach to process development.
Chen, CK
Singh, AK
Grosso, JA
Venit, JJ
Qiu, J
Dadiz, A
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 222 : U641 - U641
[36] Synthesizing schizophrenia: A bottom-up, symptomatic approach
Robbins, TW
SCHIZOPHRENIA BULLETIN, 2005, 31 (04) : 854 - 864
[37] Governing Campus Speech: a Bottom-Up Approach
Emily Chamlee-Wright
Society, 2018, 55 : 392 - 402
[38] Food security in India: The bottom-up approach
Bhadra, Rumela
Resource: Engineering and Technology for Sustainable World, 2013, 20 (06): : 8 - 9
[39] A bottom-up approach to the strong CP problem
Diaz-Cruz, J. L.
Hollik, W. G.
Saldana-Salazar, U. J.
INTERNATIONAL JOURNAL OF MODERN PHYSICS A, 2018, 33 (14-15):
[40] Lower Bounds on Intermediate Results in Bottom-Up Knowledge Compilation
de Colnet, Alexis
Mengel, Stefan
THIRTY-SIXTH AAAI CONFERENCE ON ARTIFICIAL INTELLIGENCE / THIRTY-FOURTH CONFERENCE ON INNOVATIVE APPLICATIONS OF ARTIFICIAL INTELLIGENCE / THE TWELVETH SYMPOSIUM ON EDUCATIONAL ADVANCES IN ARTIFICIAL INTELLIGENCE, 2022, : 5564 - 5572

← 1 2 3 4 5 →