Gold Nanoparticle-Based Biodetection for Chip-Based Portable Diagnosis Systems

被引：6
|
作者：
Li, Shifeng [1 ]
Goluch, Edgar [1 ]
Liu, Chang [1 ]
Szegedi, Sandra [1 ]
Shaikh, Kashan [1 ]
Ahmed, Faysal [1 ]
Hu, Alan [1 ]
Zhao, Shenshen [1 ]
机构：
[1] Northwestern Univ, Dept Mech Engn, MedX Lab, McCormick Sch Engn, Evanston, IL 60208 USA
来源：
JALA | 2010年 / 15卷 / 02期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
gold nanoparticles; lab-on-chip; biobarcode; DIP-PEN NANOLITHOGRAPHY; SILICONE ELASTOMER; DNA DETECTION; ARRAY; AMPLIFICATION; SENSITIVITY; PROBES; ASSAY; PCR;
D O I：
10.1016/j.jala.2009.11.001
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
We review the past development of highly sensitive and selective gold nanoparticle (AuNP)-based assays of protein and DNA biomarkers for chip-based detection systems. The microfluidic systems, various assays, and preliminary laboratory results are shown. AuNP-based biodetection assays provide low detection threshold, offering promises for multiplexed diagnostics of many forms of disease markers. (JALA 2010;15:107-13)
引用
收藏
页码：107 / 113
页数：7
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