Sulfurated diketopiperazines from an algicolous isolate of Trichoderma virens

被引:28
|
作者
Shi, Zhen-Zhen [1 ,2 ]
Miao, Feng-Ping [1 ]
Fang, Sheng-Tao [1 ]
Yin, Xiu-Li [1 ]
Ji, Nai-Yun [1 ]
机构
[1] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
基金
中国国家自然科学基金;
关键词
Trichoderma; Diketopiperazine; Gliotoxin; Sulfide; MARINE-DERIVED FUNGUS; PENICILLIUM-BROCAE MA-231; SEA LAMPREY; GLIOTOXIN; PRODUCTS; METABOLITES; DERIVATIVES;
D O I
10.1016/j.phytol.2018.07.005
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Two new naturally occurring sulfurated diketopiperazines, dehydroxymethylbis(dethio)bis(methylthio)gliotoxin (1) and (3S,6R)-6-(para-hydroxybenzyl)-1,4-dimethyl-3,6-bis(methylthio)piperazine-2,5-dione (2), along with three known analogues (3-5) were isolated from the culture extract of Trichoderma virens Y13-3, obtained from the surface of the marine red alga Gracilaria vermiculophylla. The structures and relative configurations of 1 and 2 were determined by extensive 1D/2D NMR, MS, and IR spectroscopic data, and their absolute configurations were established by analysis of ECD spectra aided by quantum chemical calculations. Compounds 1-5 were evaluated for the inhibition of some marine-derived organisms.
引用
收藏
页码:101 / 104
页数:4
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