Diastereoselective addition of silyl metals to γ-alkoxy substituted α,β-unsaturated esters

被引：3
|
作者：
Krief, A
Dumont, W
Baillieul, D
机构：
[1] Fac Univ Notre Dame Paix, Dept Chem, Lab Chim Organ Synth, B-5000 Namur, Belgium
[2] Fonds Format Rech Ind & Agr, B-1000 Brussels, Belgium
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 06期
关键词：
D O I：
10.1016/j.tetlet.2004.12.064
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Dimethylphenylsilyllithium adds to Z-gamma-alkoxy-alpha,beta-unsaturated esters to produce almost exclusively (i) the anti-adducts when the reaction is carried out in THF and (ii) the anti-adduct when carried out in the presence of HMPA. Poor stereocontrol is achieved with stereoisomeric E-gamma-alkoxy-alpha,beta-unsaturated esters. (C) 2004 Published by Elsevier Ltd.
引用
收藏
页码：951 / 953
页数：3
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