Aerosol Therapy for Pneumonia in the Intensive Care Unit

被引：13

作者：

Luyt, Charles-Edouard ^{[1
]}

Hekimian, Guillaume ^{[1
]}

Brechot, Nicolas ^{[1
]}

Chastre, Jean ^{[1
,2
]}

机构：

[1] Grp Hosp Pitie Salpetriere, AP HP, Inst Cardiol, Serv Reanimat Med, 47-83 Blvd Hop, F-75651 Paris 13, France

[2] UPMC Univ Paris 06, Sorbonne Univ, INSERM, UMRS 1166,ICAN Inst Cardiometab & Nutr, Paris, France

来源：

CLINICS IN CHEST MEDICINE | 2018年 / 39卷 / 04期

关键词：

Ventilator-associated pneumonia; Aerosol; Amikacin; Colistin; VENTILATOR-ASSOCIATED PNEUMONIA; RESISTANT ACINETOBACTER-BAUMANNII; MECHANICAL VENTILATION; IN-VITRO; COLISTIMETHATE SODIUM; NEBULIZED ANTIBIOTICS; ANTIINFECTIVE AGENTS; ADJUNCTIVE TREATMENT; INHALED ANTIBIOTICS; LINING FLUID;

D O I：

10.1016/j.ccm.2018.08.005

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Antibiotic aerosolization in patients with ventilator-associated pneumonia (VAP) allows very high concentrations of antimicrobial agents in the respiratory secretions, far more than those achievable using the intravenous route. However, data in critically ill patients with pneumonia are limited. Administration of aerosolized antibiotics might increase the likelihood of clinical resolution, but no significant improvements in important outcomes have been consistently documented. Thus, aerosolized antibiotics should be restricted to the treatment of extensively resistant gram-negative pneumonia. In these cases, the use of a vibrating-mesh nebulizer seems to be more efficient, but specific settings and conditions are required to improve lung delivery.

引用

页码：823 / +

页数：16

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