Efficient Synthesis of C-N-Coupled Heterobiaryls by Sequential N-H Functionalization Reactions

被引：55

作者：

Lee, Dong Jin ^{[1
]}

Yoo, Eun Jeong ^{[1
]}

机构：

[1] Kangwon Natl Univ, Dept Chem, Chunchon 200701, South Korea

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

MURRASTIFOLINE-A; ALKALOIDS; AMINATION; INDOLES; ARYLATION; INSERTION;

D O I：

10.1021/acs.orglett.5b00625

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

C-N-coupled heterobiaryls were synthesized by sequential N-H functionalization reactions: stereoselective rhodium-catalyzed N-H insertion, followed by regioselective palladium-catalyzed C-H amination. Because of the good substrate scope and excellent selectivity, the developed method presents a novel approach for the synthesis of heterobiaryls, which are potent antibiotics.

引用

页码：1830 / 1833

页数：4

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