Intrasteric regulation of MDM2

被引：24
|
作者：
Shimizu, H [1 ]
Hupp, TR [1 ]
机构：
[1] Univ Dundee, Dept Mol & Cellular Pathol, Canc Res UK Labs, Dundee DD1 9SY, Scotland
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2003年 / 28卷 / 07期
关键词：
D O I：
10.1016/S0968-0004(03)00140-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The oncoprotein murine double minute 2 (MDM2) binds to the tumour suppressor protein p53 and negatively regulates growth suppression by catalyzing the ubiquitination and degradation of p53. Antagonizing MDM2 is an ataxia telangiectasia mutated (ATM) kinase- and checkpoint kinase-2 (CHK2) -dependent DNA-damage-inducible pathway that phosphorylates p53, releases p53 from MDM2 control and stabilizes the p300-p53 transcription complex. A recent report has identified a pseudo-substrate domain in MDM2 that can act as a lid to cover the hydrophobic MDM2-pocket and suggests a novel mechanism for control of the stability of the MDM2-p53 protein complex in vivo.
引用
收藏
页码：346 / 349
页数：4
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