Genetics and developmental pathology of twinning

被引：56
|
作者：
Weber, Martin A. [1 ]
Sebire, Neil J. [1 ,2 ]
机构：
[1] Great Ormond St Hosp Sick Children, Dept Paediat Pathol, London WC1N 3JH, England
[2] UCL, Inst Child Hlth, London, England
来源：
SEMINARS IN FETAL & NEONATAL MEDICINE | 2010年 / 15卷 / 06期
关键词：
Congenital malformations; Conjoined twins; Perinatal mortality; TRAP sequence; Twin pregnancy; CONJOINED TWINS; PERINATAL-MORTALITY; BIRTH-DEFECTS; FETAL; PREVALENCE; GESTATIONS; SEQUENCE; HEART; RISK;
D O I：
10.1016/j.siny.2010.06.002
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Twin pregnancy is associated with a high risk of congenital malformations. This review covers the risk of such anomalies in both dizygotic and monozygotic twin pregnancies, and discusses current insights into the associations relating to zygosity, chorionicity and genetic factors. The pathological basis of specific malformations unique to the monochorionic twinning process, including conjoined twinning and twin reversed arterial perfusion (TRAP) sequence, is discussed in more detail, and factors contributing to the higher perinatal mortality rate in multiple pregnancies are addressed. (C) 2010 Elsevier Ltd. All rights reserved.
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页码：313 / 318
页数：6
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