Methylation Alkynylation of Terminal Alkenes via 1,2-Alkynyl Migration Using Dicumyl Peroxide as the Methyl Source

被引：3

作者：

Qin, Yi-qun ^{[1
]}

Chen, De ^{[1
]}

Liu, Liang ^{[1
]}

Zhang, Jia-jia ^{[1
]}

Peng, Xin-ju ^{[1
]}

Luo, Yong-yue ^{[2
]}

Deng, Wei ^{[1
]}

Xiang, Jiannan ^{[1
]}

机构：

[1] Hunan Univ, Coll Chem & Chem Engn, Adv Catalyt Engineer Res Ctr Educ, Changsha 410082, Hunan, Peoples R China

[2] Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 440800, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2021年 / 53卷 / 24期

基金：

中国国家自然科学基金;

关键词：

alkene difunctionalization; migration reaction; radical; C-H METHYLATION; UNACTIVATED ALKENES; CATALYZED METHYLATION; CARBOXYLIC-ACIDS; ALLYLIC ALCOHOLS; CYANO MIGRATION; DIFUNCTIONALIZATION; BOND; PALLADIUM; 1,2-DIFUNCTIONALIZATION;

D O I：

10.1055/a-1528-8357

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The metal-free oxidative alkene methylation/alkynylation of 1,4-enyn-3-ols with an organic peroxide as the methyl source has been developed, which provides straightforward and practical access to the challenging quaternary-carbon-containing but-3-yn-1-ones. The method is reasoned to go through methylation of functional alkenes utilizing dicumyl peroxide as the methylating reagent and subsequent intermolecular cyclization/1,2-alkynyl migration. This reaction has an excellent functional group tolerance, broad substrate scope, and exquisite selectivity.

引用

页码：4700 / 4708

页数：9

共 12 条

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