ROS signaling and redox biology in endothelial cells

被引：108

作者：

Panieri, Emiliano ^{[1
]}

Santoro, Massimo M. ^{[2
,3
]}

机构：

[1] Univ Turin, Ctr Mol Biotechnol, Dept Mol Biotechnol & Hlth Sci, Turin, Italy

[2] VIB, Vesalius Res Ctr, Lab Endothelial Mol Biol, B-3000 Leuven, Belgium

[3] Univ Leuven, Dept Oncol, Lab Endothelial Mol Biol, B-3000 Leuven, Belgium

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2015年 / 72卷 / 17期

关键词：

Reactive Oxygen Species; Redox signaling; Angiogenesis; Genetically-encoded sensors; Redox compartmentalization; Pathological angiogenesis; NF-KAPPA-B; GROWTH-FACTOR-RECEPTOR; NITRIC-OXIDE SYNTHASE; PROTEIN-TYROSINE PHOSPHATASES; IMAGING HYDROGEN-PEROXIDE; SULFENIC ACID FORMATION; AKT/PROTEIN KINASE-B; REACTIVE OXYGEN; NADPH-OXIDASE; OXIDATIVE STRESS;

D O I：

10.1007/s00018-015-1928-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The purpose of this review is to provide an overview of redox mechanisms, sources and antioxidants that control signaling events in ECs. In particular, we describe which molecules are involved in redox signaling and how they influence the relationship between ECs and other vascular component with regard to angiogenesis. Recent and new tools to investigate physiological ROS signaling will be also discussed. Such findings are providing an overview of the ROS biology relevant for endothelial cells in the context of normal and pathological angiogenic conditions.

引用

页码：3281 / 3303

页数：23

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