Epitope mapping of a monoclonal antibody specific to feline panleukopenia virus and mink enteritis virus

被引：18
|
作者：
Horiuchi, M
Mochizuki, M
Ishiguro, N
Nagasawa, H
Shinagawa, M
机构：
[1] OBIHIRO UNIV AGR & VET MED,RES CTR PROTOZOAN MOL IMMUNOL,OBIHIRO,HOKKAIDO 080,JAPAN
[2] KYORITSU SHOJI CO,LAB CLIN MICROBIOL,CHIYODA KU,TOKYO 102,JAPAN
来源：
JOURNAL OF VETERINARY MEDICAL SCIENCE | 1997年 / 59卷 / 02期
关键词：
canine parvovirus; feline panleukopenia virus; monoclonal antibody;
D O I：
10.1292/jvms.59.133
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
To obtain monoclonal antibodies (MAbs) specific to feline panleukopenia virus (FPLV) and mink enteritis virus (MEV), 15 hybridomas secreting MAbs against MEV-Abashiri were established and the properties of the MAbs were analyzed. The cross-reactivity of MAbs revealed that one MAb, P2-215 was specific for FPLV and MEV, whereas the remaining fourteen MAbs reacted with canine parvovirus (CPV), FPLV, and MEV. Epitope analyses using various CPV/MEV chimeric viruses revealed that the MAb P2-215 recognized the epitope comprised of amino acid 93-Lys in VP2, which is known to be FPLV and MEV-specific.
引用
收藏
页码：133 / 136
页数：4
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