Design and Subject Characteristics in the Federally-Funded Citalopram Trial in Children with Pervasive Developmental Disorders

被引：6

作者：

Scahill, Lawrence ^{[1
,2
]}

McCracken, James T. ^{[3
]}

Bearss, Karen ^{[1
,2
]}

Robinson, Fay ^{[4
]}

Hollander, Eric ^{[5
]}

King, Bryan ^{[6
]}

Bregman, Joel ^{[7
]}

Sikich, Lin ^{[8
]}

Dukes, Kimberly ^{[4
]}

Sullivan, Lisa ^{[9
]}

Anagnostou, Evdokia ^{[5
]}

Donnelly, Craig ^{[6
]}

Kim, Young-Shin

Ritz, Louise ^{[10
]}

Hirtz, Deborah ^{[11
]}

Wagner, Ann ^{[10
]}

机构：

[1] Yale Univ, Sch Nursing, New Haven, CT 06536 USA

[2] Yale Univ, Ctr Child Study, New Haven, CT 06536 USA

[3] Univ Calif Los Angeles, Los Angeles, CA USA

[4] DM STAT, Boston, MA USA

[5] Mt Sinai Sch Med, New York, NY USA

[6] Dartmouth Med Sch, Hanover, NH USA

[7] N Shore Long Isl Jewish Hlth Syst, Manhasset, NY USA

[8] Univ N Carolina, Chapel Hill, NC USA

[9] Boston Univ, Boston, MA 02215 USA

[10] NIMH, Bethesda, MD 20892 USA

[11] Natl Inst Neurol Disorders & Stroke, Bethesda, MD USA

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2012年 / 42卷 / 03期

关键词：

Autism; Serotonin reuptake inhibitors; Citalopram; Double-blind method; Repetitive behavior; AUTISM SPECTRUM DISORDERS; GASTROINTESTINAL SYMPTOMS; YOUNG-PEOPLE; RISPERIDONE; PREVALENCE;

D O I：

10.1007/s10803-011-1251-8

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

The Studies to Advance Autism Research and Treatment Network conducted a randomized trial with citalopram in children with Pervasive developmental disorders (PDDs). We present the rationale, design and sample characteristics of the citalopram trial. Subjects (128 boys, 21 girls) had a mean age of 9.3 (+/- 3.12) years; 132 (88.6%) were diagnosed with autistic disorder (4.7% with Asperger's Disorder; 6.7% with PDD-not otherwise specified). Less than half of the subjects were intellectually disabled; 117 (78.5%) were rated Moderate or Marked on the Clinical Global Impression for Severity. Study measures were similar to previous Research Units on Pediatric Psychopharmacology trials. Subjects in this trial were slightly older and more likely to have complaints of repetitive behavior than participants in RUPP trials.

引用

页码：432 / 440

页数：9

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