Risk factors and peripheral biomarkers for schizophrenia spectrum disorders: an umbrella review of meta-analyses

被引:108
|
作者
Belbasis, L. [1 ]
Kohler, C. A. [2 ]
Stefanis, N. [3 ]
Stubbs, B. [4 ,5 ]
van Os, J. [6 ,7 ]
Vieta, E. [8 ,9 ]
Seeman, M. V. [10 ]
Arango, C. [11 ]
Carvalho, A. F. [12 ,13 ]
Evangelou, E. [1 ,14 ]
机构
[1] Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina, Greece
[2] Univ Fed Ceara, Dept Clin Med, Translat Psychiat Res Grp, Sch Med, Fortaleza, Ceara, Brazil
[3] Natl & Kapodistrian Univ Athens, Dept Psychiat, Eginit Hosp, Sch Med, Athens, Greece
[4] South London & Maudsley NHS Fdn Trust, Dept Physiotherapy, London, England
[5] Kings Coll London, Dept Hlth Serv & Populat Res, Inst Psychiat, London, England
[6] Univ Med Ctr Utrecht, Dept Psychiat, Brain Ctr Rudolf Magnus, Utrecht, Netherlands
[7] Kings Coll London, Dept Psychosis Studies, Inst Psychiat, London, England
[8] Univ Barcelona, Bipolar Disorder Unit, IDIBAPS, Inst Neurosci, Barcelona, Spain
[9] CIBERSAM, Barcelona, Spain
[10] Univ Toronto, Inst Med Sci, Toronto, ON, Canada
[11] Univ Complutense Madrid, Dept Child & Adolescent Psychiat, CIBERSAM, Univ Hosp Gregorio Maranon,CIBERSAM,Med Sch, Madrid, Spain
[12] Univ Toronto, Dept Psychiat, Toronto, ON, Canada
[13] CAMH, Toronto, ON, Canada
[14] Imperial Coll London, Dept Epidemiol & Biostat, Sch Publ Hlth, London, England
关键词
epidemiology; meta-analysis; psychosis; risk factors; schizophrenia; SYSTEMATIC REVIEWS; CANNABIS USE; MENDELIAN RANDOMIZATION; LIFE EVENTS; ASSOCIATION; PSYCHOSIS; DISEASE; POPULATION; BIAS; HETEROGENEITY;
D O I
10.1111/acps.12847
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
ObjectiveThis study aimed to systematically appraise the meta-analyses of observational studies on risk factors and peripheral biomarkers for schizophrenia spectrum disorders. MethodsWe conducted an umbrella review to capture all meta-analyses and Mendelian randomization studies that examined associations between non-genetic risk factors and schizophrenia spectrum disorders. For each eligible meta-analysis, we estimated the summary effect size estimate, its 95% confidence and prediction intervals and the I-2 metric. Additionally, evidence for small-study effects and excess significance bias was assessed. ResultsOverall, we found 41 eligible papers including 98 associations. Sixty-two associations had a nominally significant (P-value <0.05) effect. Seventy-two of the associations exhibited large or very large between-study heterogeneity, while 13 associations had evidence for small-study effects. Excess significance bias was found in 18 associations. Only five factors (childhood adversities, cannabis use, history of obstetric complications, stressful events during adulthood, and serum folate level) showed robust evidence. ConclusionDespite identifying 98 associations, there is only robust evidence to suggest that cannabis use, exposure to stressful events during childhood and adulthood, history of obstetric complications, and low serum folate level confer a higher risk for developing schizophrenia spectrum disorders. The evidence on peripheral biomarkers for schizophrenia spectrum disorders remains limited.
引用
收藏
页码:88 / 97
页数:10
相关论文
共 50 条
  • [41] Dietary Factors and Pancreatic Cancer Risk: An Umbrella Review of Meta-Analyses of Prospective Observational Studies
    Qin, Xianpeng
    Chen, Jing
    Jia, Guiqing
    Yang, Zhou
    ADVANCES IN NUTRITION, 2023, 14 (03) : 451 - 464
  • [42] Risk factors and therapies in vascular diseases: An umbrella review of updated systematic reviews and meta-analyses
    Hong, Xing-yu
    Lin, Jie
    Gu, Wei-wei
    JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (06) : 8221 - 8232
  • [43] Risk and protective factors for mental disorders with onset in childhood/adolescence: An umbrella review of published meta-analyses of observational longitudinal studies
    Solmi, Marco
    Dragioti, Elena
    Arango, Celso
    Radua, Joaquim
    Ostinelli, Edoardo
    Kilic, Ozge
    Yilmaz, Ugur Eser
    Yalcinay-Inan, Merve
    Soares, Fernanda Cunha
    Mariano, Luca
    Mosillo, Pierluca
    Cortese, Samuele
    Correll, Christoph U.
    Carvalho, Andre F.
    Shin, Jae Il
    Fusar-Poli, Paolo
    NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2021, 120 : 565 - 573
  • [44] Genetics of autism spectrum disorder: an umbrella review of systematic reviews and meta-analyses
    Qiu, Shuang
    Qiu, Yingjia
    Li, Yan
    Cong, Xianling
    TRANSLATIONAL PSYCHIATRY, 2022, 12 (01)
  • [45] Genetics of autism spectrum disorder: an umbrella review of systematic reviews and meta-analyses
    Shuang Qiu
    Yingjia Qiu
    Yan Li
    Xianling Cong
    Translational Psychiatry, 12
  • [46] The genetics of drug-related movement disorders, an umbrella review of meta-analyses
    Nadine C. van der Burg
    Asmar F. Y. Al Hadithy
    Peter N. van Harten
    Jim van Os
    P. Roberto Bakker
    Molecular Psychiatry, 2020, 25 : 2237 - 2250
  • [47] The genetics of drug-related movement disorders, an umbrella review of meta-analyses
    van der Burg, Nadine C.
    Al Hadithy, Asmar F. Y.
    Van Harten, Peter N.
    van Os, Jim
    Bakker, P. Roberto
    MOLECULAR PSYCHIATRY, 2020, 25 (10) : 2237 - 2250
  • [48] THE GENETICS OF DRUG-RELATED MOVEMENT DISORDERS AN UMBRELLA REVIEW OF META-ANALYSES
    van der Burg, Nadine
    Bakker, P. Roberto
    Os, Jim Van
    Van Harten, Peter
    Al Hadithy, Asmar
    SCHIZOPHRENIA BULLETIN, 2018, 44 : S295 - S295
  • [49] Biomarkers and Related Factors for the Diagnosis, Risk of Coronary Artery Lesions, and Resistance to Intravenous Immunoglobulin in Kawasaki Disease: An Umbrella Review of Meta-Analyses
    Kim, Tae Hyeon
    Son, Yejun
    Lee, Hyeri
    Lee, Kyeongmin
    Lee, Hayeon
    Park, Jaeyu
    Kim, Soeun
    Smith, Lee
    Lee, Sooji
    Jeong, Yi Deun
    Jo, Hyesu
    Udeh, Raphael
    Pizzol, Damiano
    Kang, Jiseung
    Yon, Dong Keon
    PEDIATRIC CARDIOLOGY, 2024,
  • [50] Autism Spectrum Disorders and Malocclusions: Systematic Review and Meta-Analyses
    Barros, Aline
    Mascarenhas, Paulo
    Botelho, Joao
    Machado, Vanessa
    Balixa, Gabriela
    Bandeira Lopes, Luisa
    JOURNAL OF CLINICAL MEDICINE, 2022, 11 (10)