Ethyl p-methoxycinnamate isolated from a traditional anti-tuberculosis medicinal herb inhibits drug resistant strains of Mycobacterium tuberculosis in vitro

被引：64
|
作者：
Lakshmanan, Divya [1 ]
Werngren, Jim [3 ]
Jose, Leny [1 ]
Suja, K. P. [1 ]
Nair, Mangalam S. [2 ]
Varma, R. Luxmi [2 ]
Mundayoor, Sathish [1 ]
Hoffner, Sven [3 ]
Kumar, R. Ajay [1 ]
机构：
[1] Rajiv Gandhi Ctr Biotechnol, Dept Mol Microbiol, Thiruvananthapuram 695014, Kerala, India
[2] CSIR, Natl Inst Interdisciplinary Sci & Technol, Organ Chem Sect, Thiruvananthapuram 695019, Kerala, India
[3] Swedish Inst Infect Dis Control, Dept Bacteriol, SE-17182 Solna, Sweden
来源：
FITOTERAPIA | 2011年 / 82卷 / 05期
关键词：
Antimycobacterial; M; tuberculosis; K; galanga; Ethyl p-methoxycinnamate; REMA;
D O I：
10.1016/j.fitote.2011.03.006
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Many plants are used in Ayurveda for the treatment of tuberculosis. Our aim was to examine if these plants possess any specific molecule that inhibits Mycobacterium tuberculosis. One of them, Kaempferia galanga, yielded an anti-TB molecule, ethyl p-methoxycinnamate (EPMC). By resazurin microtitre assay (REMA). EPMC was shown to inhibit M. tuberculosis H37Ra, H37Rv, drug susceptible and multidrug resistant (MDR) clinical isolates (MIC 0.242-0.485 mM). No cross resistance was observed to any standard anti-TB drugs in the MDR strains. The compound did not inhibit any prototype bacteria tested. EPMC seems to be a potential anti-TB lead molecule. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：757 / 761
页数：5
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