Novel Chiral Skeletons for Drug Discovery: Antibacterial Tetramic Acids

被引：26

作者：

Holloway, Chloe A. ^{[1
]}

Matthews, Christopher J. ^{[1
]}

Jeong, Yong-Chul ^{[1
]}

Moloney, Mark G. ^{[1
]}

Roberts, Christine F. ^{[1
]}

Yaqoob, Muhammad ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

来源：

CHEMICAL BIOLOGY & DRUG DESIGN | 2011年 / 78卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

drug design; molecular diversity; natural product; NATURAL-PRODUCTS; INHIBITORS; MOLECULES; CHEMISTRY; DESIGN; POTENT;

D O I：

10.1111/j.1747-0285.2011.01133.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Modification of the ring nucleus of tetramic acids derived from serine gives chiral heterocyclic libraries that exhibit antibacterial activity, and correlation with various physicochemical parameters indicates that chiral tetramic acids may provide a potentially valuable non-aromatic skeleton for fragment-based drug discovery.

引用

页码：229 / 235

页数：7

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