Novel Chiral Skeletons for Drug Discovery: Antibacterial Tetramic Acids

被引：26

作者：

Holloway, Chloe A. ^{[1
]}

Matthews, Christopher J. ^{[1
]}

Jeong, Yong-Chul ^{[1
]}

Moloney, Mark G. ^{[1
]}

Roberts, Christine F. ^{[1
]}

Yaqoob, Muhammad ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

来源：

CHEMICAL BIOLOGY & DRUG DESIGN | 2011年 / 78卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

drug design; molecular diversity; natural product; NATURAL-PRODUCTS; INHIBITORS; MOLECULES; CHEMISTRY; DESIGN; POTENT;

D O I：

10.1111/j.1747-0285.2011.01133.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Modification of the ring nucleus of tetramic acids derived from serine gives chiral heterocyclic libraries that exhibit antibacterial activity, and correlation with various physicochemical parameters indicates that chiral tetramic acids may provide a potentially valuable non-aromatic skeleton for fragment-based drug discovery.

引用

页码：229 / 235

页数：7

共 50 条

[1] DIASTEREOFACIAL SELECTIVITY IN REDUCTION OF CHIRAL TETRAMIC ACIDS
GALEOTTI, N
PONCET, J
CHICHE, L
JOUIN, P
JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (20): : 5370 - 5376
[2] AROMATIC DIENOYL TETRAMIC ACIDS - NOVEL ANTIBACTERIAL AGENTS WITH ACTIVITY AGAINST ANAEROBES AND STAPHYLOCOCCI
ROSEN, T
FERNANDES, PB
MAROVICH, MA
SHEN, L
MAO, J
PERNET, AG
JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (05) : 1062 - 1069
[3] AROMATIC DIENOYL TETRAMIC ACIDS - NOVEL ANTIBACTERIAL AGENTS WITH ACTIVITY AGAINST ANAEROBES AND STAPHYLOCOCCI
ROSEN, T
FERNANDES, PB
SHEN, L
MAROVICH, MA
MAO, J
PERNET, A
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1988, 195 : 62 - MEDI
[4] Antisense peptide nucleic acids in antibacterial drug discovery
Burnham, M
Ji, YD
MOLECULAR THERAPY, 2004, 10 (04) : 614 - 615
[5] Tetramic Acids as Scaffolds: Synthesis, Tautomeric and Antibacterial Behaviour
Jeong, Yong-Chul
Moloney, Mark G.
SYNLETT, 2009, (15) : 2487 - 2491
[6] Innovative approaches to novel antibacterial drug discovery
Trias, J
Gordon, EM
CURRENT OPINION IN BIOTECHNOLOGY, 1997, 8 (06) : 757 - 762
[7] Design, synthesis, and biological evaluation of tetramic acids as antibacterial agents
Yendapally, Raghunandan
Carson, Elizabeth I.
Lee, Robin E. B.
Lee, Richard E.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 233 : 786 - 786
[8] Novel strategies for antibacterial drug discovery - antitoxin drugs
Jagusztyn-Krynicka, Elzbieta Katarzyna
Rybacki, Jakub
Lasica, Anna Maria
POSTEPY MIKROBIOLOGII, 2009, 48 (02): : 93 - 104
[9] TETRAMIC ACIDS AS NOVEL GLYCINE SITE ANTAGONISTS
MAWER, IM
KULAGOWSKI, JJ
LEESON, PD
GRIMWOOD, S
MARSHALL, GR
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (22) : 2643 - 2648
[10] Antibacterial drug discovery
VanBogelen, Ruth A.
Brzezinski, Erin E.
MOLECULAR & CELLULAR PROTEOMICS, 2004, 3 (10) : S159 - S159

← 1 2 3 4 5 →