Adeno-Associated Viral Vectors in Neuroscience Research

被引：69

作者：

Haggerty, David L. ^{[1
]}

Grecco, Gregory G. ^{[1
,2
]}

Reeves, Kaitlin C. ^{[1
]}

Atwood, Brady ^{[1
,3
]}

机构：

[1] Indiana Univ Sch Med, Dept Pharmacol & Toxicol, 320 West 15th St,NB-400C, Indianapolis, IN 46202 USA

[2] Indiana Univ Sch Med, Med Scientist Training Program, Indianapolis, IN 46202 USA

[3] Stark Neurosci Res Inst, Indianapolis, IN 46202 USA

来源：

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT | 2020年 / 17卷

关键词：

GENE-THERAPY VECTOR; PARKINSONS-DISEASE; VIRUS AAV; DOUBLE-BLIND; SEROTYPES; OPEN-LABEL; EFFICIENT TRANSDUCTION; ALIPOGENE TIPARVOVEC; ALZHEIMERS-DISEASE; SUBSTANTIA-NIGRA;

D O I：

10.1016/j.omtm.2019.11.012

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Adeno-associated viral vectors (AAVs) are increasingly useful preclinical tools in neuroscience research studies for interrogating cellular and neurocircuit functions and mapping brain connectivity. Clinically, AAVs are showing increasing promise as viable candidates for treating multiple neurological diseases. Here, we briefly review the utility of AAVs in mapping neuro-circuits, manipulating neuronal function and gene expression, and activity labeling in preclinical research studies as well as AAV-based gene therapies for diseases of the nervous system. This review highlights the vast potential that AAVs have for transformative research and therapeutics in the neurosciences.

引用

页码：69 / 82

页数：14

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