First Outbreak of a Plasmid-Mediated Carbapenem-Hydrolyzing OXA-48 β-Lactamase in Klebsiella pneumoniae in Spain

被引：117

作者：

Pitart, Cristina

Sole, Mar

Roca, Ignasi

Fabrega, Anna

Vila, Jordi

Marco, Francesc

机构：

[1] Univ Barcelona, Dept Clin Microbiol, Sch Med, Hosp Clin IDIBAPS, Barcelona, Spain

[2] Barcelona Ctr Int Hlth Res, Barcelona, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 09期

关键词：

RESISTANCE; EMERGENCE; IMIPENEM; SPREAD; TURKEY; GENES;

D O I：

10.1128/AAC.00329-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Twenty Klebsiella pneumoniae isolates producing OXA-48 were collected from April 2009 to September 2010. Strains were clonally related and coproduced a CTX-M-15 beta-lactamase. A conjugative plasmid of circa 70 kb carrying bla OXA-48 was identified. Eleven isolates showed low-level resistance to carbapenems, whereas nine showed high-level resistance. Decreased expression of OmpK36 was related to high-level resistance to carbapenems. The isolates belonged to sequence type 101 (ST101). This is the first outbreak caused by an OXA-48-producing K. pneumoniae strain in Spain.

引用

页码：4398 / 4401

页数：4

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