A study of the effect on human mesenchymal stem cells of an atmospheric pressure plasma source driven by different voltage waveforms

被引：5
|
作者：
Laurita, R. [1 ]
Alviano, F. [2 ]
Marchionni, C. [2 ]
Abruzzo, P. M. [2 ]
Bolotta, A. [2 ]
Bonsi, L. [2 ]
Colombo, V. [1 ,5 ]
Gherardi, M. [1 ,5 ]
Liguori, A. [1 ]
Ricci, F. [3 ]
Rossi, M. [2 ]
Stancampiano, A. [1 ]
Tazzari, P. L. [3 ]
Marini, M. [2 ,4 ]
机构：
[1] Alma Mater Studiorum Univ Bologna, Dept Ind Engn DIN, Via Saragozza 8, I-40123 Bologna, Italy
[2] Alma Mater Studiorum Univ Bologna, Dept Expt Diagnost & Specialty Med DIMES, Via Belmeloro 8, I-40126 Bologna, Italy
[3] St Orsola Marcello Malpighi Hosp, Immunohaematol & Transfus Med Serv, Via Massarenti 9, I-40138 Bologna, Italy
[4] IRCCS S Maria Nascente, Don Gnocchi Fdn ONLUS, Via Alfonso Capecelatro 66, I-20148 Milan, Italy
[5] Alma Mater Studiorum Univ Bologna, Ind Res Ctr Adv Mech & Mat CIRIMAM, Via Saragozza 8, I-40123 Bologna, Italy
来源：
JOURNAL OF PHYSICS D-APPLIED PHYSICS | 2016年 / 49卷 / 36期
关键词：
atmospheric pressure non-equilibrium plasma; dielectric barrier discharge; high voltage pulsed discharge; fetal membrane-derived human mesenchymal stem cells; LOW-TEMPERATURE PLASMA; ELECTRICAL PULSES; ARGON PLASMA; CANCER; ELECTROPORATION; SENESCENCE; STRATEGY; CYCLE; STATE;
D O I：
10.1088/0022-3727/49/36/364003
中图分类号：
O59 [应用物理学];
学科分类号：
摘要：
The effect of an atmospheric pressure non-equilibrium plasma on human mesenchymal stem cells was investigated. A dielectric barrier discharge non-equilibrium plasma source driven by two different high-voltage pulsed generators was used and cell survival, senescence, proliferation, and differentiation were evaluated. Cells deprived of the culture medium and treated with nanosecond pulsed plasma showed a higher mortality rate, while higher survival and retention of proliferation were observed in cells treated with microsecond pulsed plasma in the presence of the culture medium. While a few treated cells showed the hallmarks of senescence, unexpected delayed apoptosis ensued in cells exposed to plasma-treated medium. The plasma treatment did not change the expression of OCT4, a marker of mesenchymal stem cell differentiation.
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页数：14
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