SYNTHESIS OF WATER-SOLUBLE POLYMERIC ESTERS OF THE ANTIBIOTIC CEFUROXIME

被引：0

作者：

Solovskii, M. V. ^{[1
]}

Borisenko, M. S. ^{[1
]}

Smirnova, M. Yu. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Macromol Cpds, St Petersburg 199004, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2012年 / 45卷 / 10期

关键词：

antibiotics; cefuroxime; poly-(N-2-hydroxypropyl)methacrylamide; polymeric esters of cefuroxime; antibacterial activity; hydrolysis in physiological solution;

D O I：

10.1007/s11094-012-0687-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Water-soluble polymeric esters of the antibiotic cefuroxime were synthesized for the first time by the carbodiimide method using low-molecular-weight poly-(N-2-hydroxypropyl)methacrylamide as a carrier. The synthesized compounds contain 16.6 and 19.5 wt% antibiotic, exhibit antibacterial activity with respect to S. aureus, and are subject to hydrolysis in physiological solution at 37 degrees C (45.4 and 53.2% for 24 and 30 h, respectively).

引用

页码：593 / 596

页数：4

共 50 条

[31] Water-Soluble Polymeric Methanofullerene and Fulleropyrrolidine Derivatives
O. V. Nazarova
I. A. Nuretdinov
A. V. Slita
G. M. Pavlov
N. P. Evlampieva
L. S. Litvinova
V. P. Gubskaya
G. M. Fazleeva
L. Sh. Berezhnaya
A. P. Pronina
O. I. Kiselev
E. F. Panarin
Russian Journal of Applied Chemistry, 2005, 78 : 1981 - 1986
[32] Water-soluble, antiyellowing polymeric fluorescence brighteners
Guo, Mingyuan
Zhang, Guanghua
Du, Lun
Zheng, Hua
Liu, Guojun
JOURNAL OF APPLIED POLYMER SCIENCE, 2017, 134 (47)
[33] Water-soluble polymeric particle embedded cryogels: Synthesis, characterisation and adsorption of haemoglobin
Erol, Kadir
Bulter, Melda Bolat
Kose, Dursun Ali
Can, Hatice Kaplan
JOURNAL OF POLYMER ENGINEERING, 2021, 41 (08) : 671 - 680
[34] Design and synthesis of polymeric membranes using water-soluble pore formers: an overview
Tabassum Malik
Humaira Razzaq
Shumaila Razzaque
Hifza Nawaz
Asima Siddiqa
Mohammad Siddiq
Sara Qaisar
Polymer Bulletin, 2019, 76 : 4879 - 4901
[35] POLY(VINYLAMINE HYDROCHLORIDE) - SYNTHESIS AND UTILIZATION FOR PREPARATION OF WATER-SOLUBLE POLYMERIC DYES
DAWSON, DJ
GLESS, RD
WINGARD, RE
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1976, 98 (19) : 5996 - 6000
[36] Synthesis of a novel water-soluble crosslinking polymeric dye with good dyeing properties
Tang, BT
Zhang, SF
Yang, JZ
Liu, F
DYES AND PIGMENTS, 2006, 68 (01) : 69 - 73
[37] Design and synthesis of polymeric membranes using water-soluble pore formers: an overview
Malik, Tabassum
Razzaq, Humaira
Razzaque, Shumaila
Nawaz, Hifza
Siddiqa, Asima
Siddiq, Mohammad
Qaisar, Sara
POLYMER BULLETIN, 2019, 76 (09) : 4879 - 4901
[38] Green synthesis of water-soluble nontoxic polymeric nanocomposites containing silver nanoparticles
Prozorova, Galina F.
Pozdnyakov, Alexsandr S.
Kuznetsova, Nadezhda P.
Korzhova, Svetlana A.
Emel'yanov, Artem I.
Ermakova, Tamara G.
Fadeeva, Tat'yana V.
Sosedova, Larisa M.
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2014, 9 : 1883 - 1889
[39] WATER-SOLUBLE ANTIFUNGAL ANTIBIOTIC FROM A STREPTOMYCES
RAO, AS
REDDI, GS
PHYTOPATHOLOGY, 1966, 56 (08) : 896 - &
[40] Synthesis of a water-soluble polyimide
Deans, Taneisha
Savant, Deepa
Schiraldi, David
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 241

← 1 2 3 4 5 →