SYNTHESIS OF WATER-SOLUBLE POLYMERIC ESTERS OF THE ANTIBIOTIC CEFUROXIME

被引：0

作者：

Solovskii, M. V. ^{[1
]}

Borisenko, M. S. ^{[1
]}

Smirnova, M. Yu. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Macromol Cpds, St Petersburg 199004, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2012年 / 45卷 / 10期

关键词：

antibiotics; cefuroxime; poly-(N-2-hydroxypropyl)methacrylamide; polymeric esters of cefuroxime; antibacterial activity; hydrolysis in physiological solution;

D O I：

10.1007/s11094-012-0687-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Water-soluble polymeric esters of the antibiotic cefuroxime were synthesized for the first time by the carbodiimide method using low-molecular-weight poly-(N-2-hydroxypropyl)methacrylamide as a carrier. The synthesized compounds contain 16.6 and 19.5 wt% antibiotic, exhibit antibacterial activity with respect to S. aureus, and are subject to hydrolysis in physiological solution at 37 degrees C (45.4 and 53.2% for 24 and 30 h, respectively).

引用

页码：593 / 596

页数：4

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