Synthesis and antibacterial properties of nitrofuryltriazolothiadiazepines

被引：0
|
作者：
Holla, BS [1 ]
Shridhara, K [1 ]
Shivananda, MK [1 ]
机构：
[1] Mangalore Univ, Dept Postgrad Studies & Res Chem, Mangalagangothri 574199, India
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2003年 / 42卷 / 12期
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D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Methyl aryl ketones I on reaction with 5-nitrofurfuraldehyde 2 give 1-aryl-3-(5-nitro-2-furyl)-2-propen- I -ones 3 which on bromination affords 2,3-dibromo- I -aryl-3-(5-nitro-2-furyl)-2-propen- I -ones 4. Debromination of 4 by triethylamine in benzene results in 1-aryl-3-(5-nitro-2-furyl)-2-propen- 1 -ones 5 which on condensation with 3-substituted-4-amino-5-mercapto-1,2,4-triazole 6 furnishes Michael adducts 7. The Michael adduct 7 undergoes cyclization in conc. sulphuric acid to give 3-aryloxymethyl-6-aryl-8-(5-nitro-2-furyl)-1,2,4-triazolothiadiazepines 8. Antibacterial activity of 7 and 8 has been reported.
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页码：3113 / 3116
页数：4
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