Pancancer cytotoxic T-cell trapping: are neutrophil extracellular traps a viable biomarker for immunotherapy response?

被引：1

作者：

Desharnais, Lysanne ^{[1
,2
]}

Spicer, Jonathan D. ^{[2
,3
]}

机构：

[1] McGill Univ, Dept Human Genet, Montreal, PQ, Canada

[2] McGill Univ, Rosalind & Morris Goodman Canc Inst, Montreal, PQ, Canada

[3] McGill Univ, Dept Surg, Montreal, PQ, Canada

来源：

JOURNAL OF PATHOLOGY | 2022年 / 256卷 / 03期

基金：

加拿大健康研究院;

关键词：

neutrophil; neutrophil extracellular trap; NETosis; IL-8; immune checkpoint inhibitors;

D O I：

10.1002/path.5844

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In a recent issue of The Journal of Pathology, a study by de Andrea, Ochoa, Villalba-Esparza et al demonstrated the presence of neutrophil extracellular traps (NETs) in a variety of human solid tumor types detected by multiplex immunofluorescence. In addition to NET identification and quantification, they found that there is individual heterogeneity in NET abundance in tumors and in circulation, and that NETs are positively associated with IL-8 and negatively associated with tumor-infiltrating CD8+ T cells. (C) 2022 The Pathological Society of Great Britain and Ireland.

引用

页码：253 / 255

页数：3

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