The Clinical Relevance of Chromogranin A as a Biomarker for Gastroenteropancreatic Neuroendocrine Tumors

被引：124
|
作者：
Lawrence, Ben [1 ]
Gustafsson, Bjorn I. [2 ,3 ]
Kidd, Mark [1 ]
Pavel, Marianne [4 ]
Svejda, Bernhard [1 ]
Modlin, Irvin M. [1 ]
机构：
[1] Yale Univ, Sch Med, Dept Surg, Gastrointestinal Pathobiol Res Grp, New Haven, CT 06520 USA
[2] St Olavs Hosp, Dept Gastroenterol, N-7006 Trondheim, Norway
[3] Norwegian Univ Sci & Technol, Dept Canc Res & Mol Med, N-7006 Trondheim, Norway
[4] Univ Med Berlin, Charite Campus Virchow Klinikum, Med Klin MS Hepatol & Gastroenterol, D-13353 Berlin, Germany
来源：
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2011年 / 40卷 / 01期
关键词：
Chromogranin; Granin family; Neuroendocrine tumor; Carcinoid; Enterochromaffin cell; Tumor marker; SOMATOSTATIN RECEPTOR SCINTIGRAPHY; ELEVATED SERUM CHROMOGRANIN; PANCREATIC ENDOCRINE TUMORS; INFLAMMATORY-BOWEL-DISEASE; REGION-SPECIFIC ANTIBODIES; NEURON-SPECIFIC ENOLASE; LONG-ACTING RELEASE; B SECRETOGRANIN-I; CARCINOID-TUMORS; FOLLOW-UP;
D O I：
10.1016/j.ecl.2010.12.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Chromogranin A, although it exhibits limitations, is currently the most useful general tumor biomarker available for use in the diagnosis and management of gastroenteropancreatic neuroendocrine tumors (NETs). The value of the chromogranin A lies in its universal cosecretion by the majority of neuroendocrine cells that persists after malignant transformation. Clinicians aware of the physiologic role of chromogranin A and its secretion in a variety of non-NET related pathologic conditions can use this protein as a moderately effective tumor biomarker in the management of GEP-NETs.
引用
收藏
页码：111 / +
页数：25
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