The Clinical Relevance of Chromogranin A as a Biomarker for Gastroenteropancreatic Neuroendocrine Tumors

被引：124
|
作者：
Lawrence, Ben [1 ]
Gustafsson, Bjorn I. [2 ,3 ]
Kidd, Mark [1 ]
Pavel, Marianne [4 ]
Svejda, Bernhard [1 ]
Modlin, Irvin M. [1 ]
机构：
[1] Yale Univ, Sch Med, Dept Surg, Gastrointestinal Pathobiol Res Grp, New Haven, CT 06520 USA
[2] St Olavs Hosp, Dept Gastroenterol, N-7006 Trondheim, Norway
[3] Norwegian Univ Sci & Technol, Dept Canc Res & Mol Med, N-7006 Trondheim, Norway
[4] Univ Med Berlin, Charite Campus Virchow Klinikum, Med Klin MS Hepatol & Gastroenterol, D-13353 Berlin, Germany
来源：
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2011年 / 40卷 / 01期
关键词：
Chromogranin; Granin family; Neuroendocrine tumor; Carcinoid; Enterochromaffin cell; Tumor marker; SOMATOSTATIN RECEPTOR SCINTIGRAPHY; ELEVATED SERUM CHROMOGRANIN; PANCREATIC ENDOCRINE TUMORS; INFLAMMATORY-BOWEL-DISEASE; REGION-SPECIFIC ANTIBODIES; NEURON-SPECIFIC ENOLASE; LONG-ACTING RELEASE; B SECRETOGRANIN-I; CARCINOID-TUMORS; FOLLOW-UP;
D O I：
10.1016/j.ecl.2010.12.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Chromogranin A, although it exhibits limitations, is currently the most useful general tumor biomarker available for use in the diagnosis and management of gastroenteropancreatic neuroendocrine tumors (NETs). The value of the chromogranin A lies in its universal cosecretion by the majority of neuroendocrine cells that persists after malignant transformation. Clinicians aware of the physiologic role of chromogranin A and its secretion in a variety of non-NET related pathologic conditions can use this protein as a moderately effective tumor biomarker in the management of GEP-NETs.
引用
收藏
页码：111 / +
页数：25
相关论文
共 50 条
  • [1] Chromogranin A Is a Reliable Biomarker for Gastroenteropancreatic Neuroendocrine Tumors in an Asian Population of Patients
    Chou, Wen-Chi
    Hung, Yu-Shin
    Hsu, Jun-Te
    Chen, Jen-Shi
    Lu, Chang-Hsien
    Hwang, Tsann-Long
    Rau, Kun-Ming
    Yeh, Kun-Yun
    Chen, Tse-Ching
    Sun, Chien-Feng
    [J]. NEUROENDOCRINOLOGY, 2012, 95 (04) : 344 - 350
  • [2] Chromogranin A: a sensitive biomarker for the detection and post-treatment monitoring of gastroenteropancreatic neuroendocrine tumors
    Singh, Simron
    Law, Calvin
    [J]. EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 2012, 6 (03) : 313 - 334
  • [3] Circulating Chromogranin A as A Marker for Monitoring Clinical Response in Advanced Gastroenteropancreatic Neuroendocrine Tumors
    Tian, Tiantian
    Gao, Jing
    Li, Na
    Li, Yanyan
    Lu, Ming
    Li, Zhongwu
    Lu, Zhihao
    Li, Jie
    Shen, Lin
    [J]. PLOS ONE, 2016, 11 (05):
  • [4] Limited role of Chromogranin A as clinical biomarker for pancreatic neuroendocrine tumors
    Pulvirenti, Alessandra
    Rao, Deepthi
    Mcintyre, Caitlin A.
    Gonen, Mithat
    Tang, Laura H.
    Klimstra, David S.
    Fleisher, Martin
    Ramanathan, Lakshmi V.
    Reidy-Lagunes, Diane
    Allen, Peter J.
    [J]. HPB, 2019, 21 (05) : 612 - 618
  • [5] Chromogranin A: any relevance in neuroendocrine tumors?
    Kidd, Mark
    Bodei, Lisa
    Modlin, Irvin M.
    [J]. CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY, 2016, 23 (01) : 28 - 37
  • [6] The Clinical Impact of Serum Chromogranin-A in Patients With Gastroenteropancreatic Neuroendocrine Tumors (GEP-NETS)
    Wu, S.
    Reta-Impey, P.
    Manivannan, N.
    Fu, P.
    Cao, S.
    Asa, S.
    Tirumani, S. H.
    Davidson, J.
    Kardan, A.
    Avril, N.
    Wojtylak, P.
    Bajor, D.
    Lee, R.
    Selfridge, E.
    Saltzman, J.
    Ammori, J.
    Hardacre, J.
    Winter, J.
    Mohamed, A.
    [J]. PANCREAS, 2021, 50 (03) : 450 - 450
  • [7] Baseline chromogranin A and its dynamics are prognostic markers in gastroenteropancreatic neuroendocrine tumors
    Rogowski, Wojciech
    Wachula, Ewa
    Lewczuk, Anna
    Kolesinska-Cwikla, Agnieszka
    Izycka-Swieszewska, Ewa
    Sulzyc-Bielicka, Violetta
    Cwikla, Jaroslaw B.
    [J]. FUTURE ONCOLOGY, 2017, 13 (12) : 1069 - 1079
  • [8] Utility of chromogranin B compared with chromogranin A as a biomarker in Japanese patients with pancreatic neuroendocrine tumors
    Miki, Masami
    Ito, Tetsuhide
    Hijioka, Masayuki
    Lee, Lingaku
    Yasunaga, Kohei
    Ueda, Keijiro
    Fujiyama, Takashi
    Tachibana, Yuichi
    Kawabe, Ken
    Jensen, Robert T.
    Ogawa, Yoshihiro
    [J]. JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2017, 47 (06) : 520 - 528
  • [9] Gastroenteropancreatic Neuroendocrine Tumors
    Cives, Mauro
    Strosberg, Jonathan R.
    [J]. CA-A CANCER JOURNAL FOR CLINICIANS, 2018, 68 (06) : 471 - 487
  • [10] Gastroenteropancreatic neuroendocrine tumors
    Rayes, Nada
    Denecke, Timm
    [J]. ONKOLOGE, 2021, 27 (05): : 511 - 520
12345