Caspase-2 cleaves DNA fragmentation factor (DFF45)/inhibitor of caspase-activated DNase (ICAD)

被引：15

作者：

Dahal, Giri Raj

Karki, Pratap

Thapa, Arjun

ShahnawaZ, Mohammad

Shin, Song Yub

Lee, Jung Sup

Cho, Byungyun

Park, Il-Seon

机构：

[1] Chosun Univ, Res Ctr Proteineous Mat, Dept Biomat Engn, Kwangju 501759, South Korea

[2] Chosun Univ, Sch Med, Dept Cellular & Mol Med, Kwangju 501759, South Korea

[3] Chosun Univ, Coll Nat Sci, Dept Biotechnol, Kwangju 501759, South Korea

[4] Yonsei Univ, Dept Chem, Wonju, South Korea

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2007年 / 468卷 / 01期

基金：

欧洲研究理事会; 新加坡国家研究基金会;

关键词：

caspase-2; Tat; apoptosis; DNA fragmentation factor;

D O I：

10.1016/j.abb.2007.09.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To investigate the signal transduction pathway of caspase-2, cell permeable Tat-reverse-caspase-2 was constructed, characterized and utilized for biochemical and cellular studies. It could induce the cell death as early as 2 h, and caspase-2-specific VDVADase activity but not other caspase activities including DEVDase and IETDase. Interestingly, nuclear DNA fragmentation occurred and consistently DNA fragmentation factor (DFF45)/Inhibitor of caspase-activated DNase (ICAD) was cleaved inside the cell as well as in vitro, suggesting a role of caspase-2 in nuclear DNA fragmentation. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：134 / 139

页数：6

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