Cu2O-catalyzed phosphonyldifluoromethylation of allylic alcohols through a radical 1,2-aryl migration

被引：14
|
作者：
Hu, Liangzhen [1 ]
Deng, Qingfu [1 ]
Zhou, Yong [1 ]
Zhang, Xiaohui [1 ]
Xiong, Yan [1 ,2 ]
机构：
[1] Chongqing Univ, Sch Chem & Chem Engn, Chongqing 401331, Peoples R China
[2] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
来源：
TETRAHEDRON | 2020年 / 76卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Cu2O-Catalyzed; Phosphonyldifluoromethylation; Allylic alcohols; 1,2-Aryl migration; CATALYZED TRIFLUOROMETHYLATION; ALKENES; REARRANGEMENT; ALPHA; FLUORINE; ACIDS;
D O I：
10.1016/j.tet.2020.130949
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Copper(I)-catalyzed phosphonyldifluoromethylation of allylic alcohols promoted by daylight is described. This method provides a facile and economic access to a series of 3-difluoromethylphosphonate-1,2-diphenylpropan-1-ones. Mechanistic studies reveal that a radical process is involved in the reaction. (C) 2020 Elsevier Ltd. All rights reserved.
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页数：8
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