Preparation and characterization of inclusion complexes of topotecan with sulfonatocalixarene

被引：50
|
作者：
Wang, Guo-Song [1 ]
Zhang, Heng-Yi [1 ]
Ding, Fei [1 ]
Liu, Yu [1 ]
机构：
[1] Nankai Univ, Dept Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
来源：
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2011年 / 69卷 / 1-2期
关键词：
Sulfonatocalixarenes; Topotecan; Supramolecular chemistry; Inclusion complexation; SALVAGE THERAPY; ONCOLOGY-GROUP; CANCER; SOLUBILIZATION; CYCLODEXTRINS; CARCINOMA;
D O I：
10.1007/s10847-010-9817-1
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Inclusion complex of sulfonatocalix[4]arene (SC4A) with topotecan (TPT) was prepared, and its inclusion complexation behaviors, such as stoichiometry, complex stability constants, and inclusion mode, were investigated by means of UV/Vis spectroscopy, DSC, and 2D NMR. The obtained results show that the quinoline ring and the dimethylaminomethyl group of TPT can be efficiently encapsulated in SC4A, and the complex is more soluble than free TPT.
引用
收藏
页码：85 / 89
页数：5
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