Reductions in liver stiffness by magnetic resonance elastography (MRE) predict fibrosis improvement in a multi-center clinical trial of subjects with nonalcoholic steatohepatitis (NASH)

被引:0
|
作者
Loomba, Rohit [1 ]
Lawitz, Eric [2 ]
Ghalib, Reem [3 ]
Elkhashab, Magdy [4 ]
Caldwell, Stephen H. [5 ]
Abdelmalek, Manal F. [6 ]
Kowdley, Kris V. [7 ]
Xu, Ren [8 ]
Han, Ling [8 ]
Li, Yao [8 ]
Djedjos, Constantine S. [8 ]
Myers, Robert P. [8 ]
Subramanian, Mani [8 ]
Goodman, Zachary D. [9 ]
Charlton, Michael [10 ]
Sirlin, Claude B. [1 ]
Middleton, Michael S. [1 ]
机构
[1] Univ Calif San Diego, San Diego, CA 92103 USA
[2] Univ Texas Hlth, Texas Liver Inst, San Antonio, TX USA
[3] Texas Clin Res Inst, Arlington, TX USA
[4] Toronto Liver Ctr, Toronto, ON, Canada
[5] Univ Virginia, Charlottesville, VA USA
[6] Duke Univ, Med Ctr, Durham, NC USA
[7] Swedish Med Ctr, Seattle, WA USA
[8] Gilead Sci, Foster City, CA USA
[9] Inova Fairfax Hosp, Falls Church, VA USA
[10] Univ Chicago, Chicago, IL 60637 USA
关键词
D O I
暂无
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
2104
引用
收藏
页码:1109A / 1110A
页数:2
相关论文
共 24 条
  • [1] Longitudinal changes in liver stiffness by magnetic resonance elastography (MRE), liver fibrosis, and serum markers of fibrosis in a multi-center clinical trial in nonalcoholic steatohepatitis (NASH)
    Loomba, R.
    Lawitz, E.
    Ghalib, R.
    Elkhashab, M.
    Caldwell, S.
    Abdelmalek, M.
    Kowdley, K.
    Xu, R.
    Chen, G.
    Djedjos, C. S.
    Myers, P.
    Subramanian, G. M.
    Goodman, Z.
    Charlton, M.
    Sirlin, C.
    Middleton, M. S.
    JOURNAL OF HEPATOLOGY, 2017, 66 (01) : S671 - S671
  • [2] Reductions in hepatic proton density fat fraction (PDFF) predict histologic improvement in a multi-center clinical trial of subjects with nonalcoholic steatohepatitis (NASH)
    Loomba, Rohit
    Lawitz, Eric
    Jayakumar, Saumya
    Mantry, Parvez S.
    Caldwell, Stephen H.
    Diehl, Anna Mae
    Xu, Ren
    Han, Ling
    Li, Yao
    Djedjos, Constantine S.
    Myers, Robert P.
    Subramanian, Mani
    Goodman, Zachary D.
    Charlton, Michael
    Afdhal, Nezam H.
    Sirlin, Claude B.
    Middleton, Michael S.
    HEPATOLOGY, 2017, 66 : 1146A - 1147A
  • [3] In a nonalcoholic steatohepatitis (NASH) clinical trial, baseline and screen failure magnetic resonance elastography (MRE) liver stiffness values calculated as weighted means were not different from values calculated as simple means
    Middleton, Michael
    Becker, Mark
    Henderson, Walter
    JOURNAL OF HEPATOLOGY, 2022, 77 : S455 - S455
  • [4] Responsiveness of controlled attenuation parameter (CAP) and its correlation with magnetic resonance imaging-proton density fat fraction (MRI-PDFF) in a multi-center clinical trial of subjects with nonalcoholic steatohepatitis (NASH)
    Noureddin, M.
    Kayali, Z.
    Harrison, S.
    Ruane, P.
    Gitlin, N.
    Lawitz, E.
    Bennett, M.
    Vuppalanchi, R.
    Freilich, B.
    Harting, E.
    Mccolgan, B.
    Myers, R.
    Middleton, M.
    Sirlin, C.
    Charlton, M.
    Lai, M.
    Mantry, P.
    Loomba, R.
    JOURNAL OF HEPATOLOGY, 2018, 68 : S564 - S565
  • [5] Magnetic Resonance Elastography Measured Shear Stiffness as a Biomarker of Fibrosis in Pediatric Nonalcoholic Fatty Liver Disease
    Schwimmer, Jeffrey B.
    Behling, Cynthia
    Angeles, Jorge Eduardo
    Paiz, Melissa
    Durelle, Janis
    Africa, Jonathan
    Newton, Kimberly P.
    Brunt, Elizabeth M.
    Lavine, Joel E.
    Abrams, Stephanie H.
    Masand, Prakash
    Krishnamurthy, Rajesh
    Wong, Kelvin
    Ehman, Richard L.
    Yin, Meng
    Glaser, Kevin J.
    Dzyubak, Bogdan
    Wolfson, Tanya
    Gamst, Anthony C.
    Hooker, Jonathan
    Haufe, William
    Schlein, Alexandra
    Hamilton, Gavin
    Middleton, Michael S.
    Sirlin, Claude B.
    HEPATOLOGY, 2017, 66 (05) : 1474 - 1485
  • [6] Clinical Utility of an Increase in Magnetic Resonance Elastography in Predicting Fibrosis Progression in Nonalcoholic Fatty Liver Disease
    Ajmera, Veeral H.
    Liu, Amy
    Singh, Seema
    Yachoa, Georg
    Ramey, Matthew
    Bhargava, Meera
    Zamani, Ava
    Lopez, Scarlett
    Mangla, Neeraj
    Bettencourt, Ricki
    Rizo, Emily
    Valasek, Mark
    Behling, Cynthia
    Richards, Lisa
    Sirlin, Claude
    Loomba, Rohit
    HEPATOLOGY, 2020, 71 (03) : 849 - 860
  • [7] RESPONSIVENESS OF CONTROLLED ATTENUATION PARAMETER (CAP) AND ITS CORRELATION WITH MAGNETIC RESONANCE IMAGING-PROTON DENSITY FAT FRACTION (MRI-PDFF) IN A MULTI-CENTER CLINICAL TRIAL OF SUBJECTS WITH NONACOHOLIC STEATOHEPATITIS (NASH)
    Noureddin, Mazen
    Kayali, Zeid
    Harrison, Stephen A.
    Ruane, Peter J.
    Gitlin, Norman
    Lawitz, Eric
    Bennett, Michael
    Vuppalanchi, Raj
    Freilich, Bradley
    Harting, Eliza
    McColgan, Bryan J.
    Natha, Macky
    Myers, Robert P.
    Middleton, Michael S.
    Sirlin, Claude B.
    Charlton, Michael
    Lai, Michelle
    Mantry, Parvez S.
    Loomba, Rohit
    GASTROENTEROLOGY, 2018, 154 (06) : S1172 - S1173
  • [8] DIAGNOSTIC ACCURACY OF MAGNETIC RESONANCE ELASTOGRAPHY IN DETECTING LIVER FIBROSIS AND NON-ALCOHOLIC STEATOHEPATITIS (NASH): A SYSTEMATIC REVIEW AND META-ANALYSIS
    Elfaituri, Muhammed Khaled Elhadi
    Khaled, Ala
    HEPATOLOGY, 2022, 76 : S857 - S857
  • [9] VALIDATION OF THE DIAGNOSTIC ACCURACY OF MAGNETIC RESONANCE ELASTOGRAPHY (MRE) FOR THE DETECTION OF ADVANCED FIBROSIS DUE TO NASH ACROSS MULTIPLE PHASE 2 AND 3 CLINICAL TRIALS
    Loomba, Rohit
    Alkhouri, Naim
    Noureddin, Mazen
    Zhang, Jie
    McColgan, Bryan J.
    Djedjos, Stephen
    Myers, Robert P.
    Middleton, Michael
    Goodman, Zachary D.
    Kowdley, Kris V.
    Nakajima, Atsushi
    Harrison, Stephen A.
    Younossi, Zobair M.
    Lawitz, Eric J.
    Wong, Vincent Wai-Sun
    Patel, Keyur
    HEPATOLOGY, 2019, 70 : 1041A - 1041A
  • [10] Evaluation of clinical applicability of automated liver parenchyma segmentation of multi-center magnetic resonance images
    Nainamalai, Varatharajan
    Prasad, Pravda Jith Ray
    Pelanis, Egidijus
    Edwin, Bjorn
    Albregtsen, Fritz
    Elle, Ole Jakob
    Kumar, Rahul P.
    EUROPEAN JOURNAL OF RADIOLOGY OPEN, 2022, 9