Fluorocarbon oligonucleotide conjugates for nucleic acids delivery

被引：34

作者：

Godeau, Guilhem ^{[1
,2
]}

Arnion, Helene ^{[1
,2
]}

Brun, Christophe ^{[1
,2
]}

Staedel, Cathy ^{[1
,2
]}

Barthelemy, Philippe ^{[1
,2
]}

机构：

[1] Univ Bordeaux, F-33076 Bordeaux, France

[2] INSERM, U869, F-33076 Bordeaux, France

来源：

MEDCHEMCOMM | 2010年 / 1卷 / 01期

关键词：

CLICK CHEMISTRY; ANTISENSE OLIGONUCLEOTIDES; TERMINAL ALKYNES; SOLID SUPPORT; DNA; HYDROCARBON; AZIDES; VIRUS; TRANSFECTION; TRANSLATION;

D O I：

10.1039/c0md00054j

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Here we describe an automated synthetic pathway for the synthesis of fluorocarbon oligonucleotide conjugates (FONs) featuring fluorocarbon hydrophobic and lipophobic moieties. The presence of highly fluorinated chains allows the delivery of nucleic acids into human cells.

引用

页码：76 / 78

页数：3

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