Discovery of JNJ-42847922, a selective orexin-2 antagonist for the treatment of insomnia disorder

被引：0

作者：

Letavic, Michael ^{[1
]}

Bonaventure, Pascal ^{[1
]}

Ly, Kiev ^{[1
]}

Aguilar, Zuleima ^{[2
]}

Aluisio, Leah ^{[1
]}

Carruthers, Nicholas ^{[1
]}

Chaplan, Sandra ^{[2
]}

Dugovic, Christine ^{[1
]}

Halter, Robin ^{[2
]}

Koudriakova, Tatiana ^{[2
]}

Lord, Brian ^{[1
]}

Lovenberg, Timothy ^{[1
]}

Kramer, Michelle ^{[2
]}

Morton, Kirsten ^{[1
]}

Ndifor, Anthony ^{[2
]}

Rizzolio, Michele ^{[2
]}

Shah, Chandra ^{[2
]}

Shelton, Jonathan ^{[1
]}

Shoblock, James ^{[1
]}

Sutton, Steven ^{[1
]}

机构：

[1] Janssen Pharmaceut Co, Neurosci Drug Discovery, San Diego, CA USA

[2] Janssen Pharmaceut Co, San Diego, CA USA

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 249卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

244

引用

页数：1

共 50 条

[31] Review of the Efficacy and Safety of Lemborexant, a Dual Receptor Orexin Antagonist (DORA), in the Treatment of Adults With Insomnia Disorder
Waters, Kristin
ANNALS OF PHARMACOTHERAPY, 2022, 56 (02) : 213 - 221
[32] Discovery of Dual Orexin Receptor Antagonists (DORAs) for the Treatment of Insomnia
Coleman, Paul J.
Cox, Christopher D.
Roecker, Anthony J.
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2011, 11 (06) : 696 - 725
[33] Daridorexant, a new dual orexin receptor antagonist, in elderly subjects with insomnia disorder
Zammit, Gary
Dauvilliers, Yves
Pain, Scott
Kinter, Dalma Sebok
Mansour, Yosef
Kunz, Dieter
NEUROLOGY, 2020, 94 (21) : E2222 - E2232
[34] Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists
Skudlarek, Jason W.
DiMarco, Christina N.
Babaoglu, Kerim
Roecker, Anthony J.
Bruno, Joseph G.
Pausch, Mark A.
O'Brien, Julie A.
Cabalu, Tamara D.
Stevens, Joanne
Brunner, Joseph
Tannenbaum, Pamela L.
Wuelfing, W. Peter
Garson, Susan L.
Fox, Steven V.
Savitz, Alan T.
Harrell, Charles M.
Gotter, Anthony L.
Winrow, Christopher J.
Renger, John J.
Kuduk, Scott D.
Coleman, Paul J.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (06) : 1364 - 1370
[35] Pharmacological characterization of the selective orexin-1 receptor antagonist JNJ-61393215 in healthy volunteers
Brooks, S.
Zuiker, R. G. J. A.
Bleys, C.
Ziagkos, D.
Moyer, J. A.
van Nueten, L.
Bonaventure, P.
Drevets, W. C.
van Gerven, J. M. A.
Salvadore, G.
Jacobs, G. E.
JOURNAL OF PSYCHOPHARMACOLOGY, 2023, 37 (06) : 577 - 589
[36] Inhibitory effects of an orexin-2 receptor antagonist on orexin A- and stress-induced ACTH responses in conscious rats
Chang, Hyukki
Saito, Tsuyoshi
Ohiwa, Nao
Tateoka, Masaru
Deocaris, Custer C.
Fujikawa, Takahiko
Soya, Hideaki
NEUROSCIENCE RESEARCH, 2007, 57 (03) : 462 - 466
[37] Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793
Preville, Cathy
Bonaventure, Pascal
Koudriakova, Tatiana
Lord, Brian
Nepomuceno, Diane
Rizzolio, Michele
Mani, Neelakandha
Coe, Kevin J.
Ndifor, Anthony
Dugovic, Christine
Dvorak, Curt A.
Coate, Heather
Pippel, Daniel J.
Fitzgerald, Anne
Allison, Brett
Lovenberg, Timothy W.
Carruthers, Nicholas, I
Shireman, Brock T.
ACS MEDICINAL CHEMISTRY LETTERS, 2020, 11 (10): : 2002 - 2009
[38] Effects of a newly developed potent orexin-2 receptor-selective antagonist, compound 1 m, on sleep/wakefulness states in mice
Etori, Keishi
Saito, Yuki C.
Tsujino, Natsuko
Sakurai, Takeshi
FRONTIERS IN NEUROSCIENCE, 2014, 8
[39] Nonclinical pharmacology of daridorexant: a new dual orexin receptor antagonist for the treatment of insomnia
Roch, Catherine
Bergamini, Giorgio
Steiner, Michel A.
Clozel, Martine
PSYCHOPHARMACOLOGY, 2021, 238 (10) : 2693 - 2708
[40] The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia Disorders
Boss, Christoph
Gatfield, John
Brotschi, Christine
Heidmann, Bibia
Sifferlen, Thierry
von Raumer, Markus
Schmidt, Gunther
Williams, Jodi T.
Treiber, Alexander
Roch, Catherine
CHEMMEDCHEM, 2020, 15 (23) : 2286 - 2305

← 1 2 3 4 5 →