JNETS clinical practice guidelines for gastroenteropancreatic neuroendocrine neoplasms: diagnosis, treatment, and follow-up: a synopsis

被引：63

作者：

Ito, Tetsuhide ^{[1
,2
]}

Masui, Toshihiko ^{[1
,2
]}

Komoto, Izumi ^{[1
,2
]}

Doi, Ryuichiro ^{[1
,2
]}

Osamura, Robert Y. ^{[1
,2
]}

Sakurai, Akihiro ^{[1
,2
]}

Ikeda, Masafumi ^{[1
,2
]}

Takano, Koji ^{[1
,2
]}

Igarashi, Hisato ^{[1
,2
]}

Shimatsu, Akira ^{[1
,2
]}

Nakamura, Kazuhiko ^{[1
,2
]}

Nakamoto, Yuji ^{[1
,2
]}

Hijioka, Susumu ^{[1
,2
]}

Morita, Koji ^{[1
,2
]}

Ishikawa, Yuichi ^{[1
,2
]}

Ohike, Nobuyuki ^{[1
,2
]}

Kasajima, Atsuko ^{[1
,2
]}

Kushima, Ryoji ^{[1
,2
]}

Kojima, Motohiro ^{[1
,2
]}

Sasano, Hironobu ^{[1
,2
]}

Hirano, Satoshi ^{[1
,2
]}

Mizuno, Nobumasa ^{[1
,2
]}

Aoki, Taku ^{[1
,2
]}

Aoki, Takeshi ^{[1
,2
]}

Ohtsuka, Takao ^{[1
,2
]}

Okumura, Tomoyuki ^{[1
,2
]}

Kimura, Yasutoshi ^{[1
,2
]}

Kudo, Atsushi ^{[1
,2
]}

Konishi, Tsuyoshi ^{[1
,2
]}

Matsumoto, Ippei ^{[1
,2
]}

Kobayashi, Noritoshi ^{[1
,2
]}

Fujimori, Nao ^{[1
,2
]}

Honma, Yoshitaka ^{[1
,2
]}

Morizane, Chigusa ^{[1
,2
]}

Uchino, Shinya ^{[1
,2
]}

Horiuchi, Kiyomi ^{[1
,2
]}

Yamasaki, Masanori ^{[1
,2
]}

Matsubayashi, Jun ^{[1
,2
]}

Sato, Yuichi ^{[1
,2
]}

Sekiguchi, Masau ^{[1
,2
]}

Abe, Shinichi ^{[1
,2
]}

Okusaka, Takuji ^{[1
,2
]}

Kida, Mitsuhiro ^{[1
,2
]}

Kimura, Wataru ^{[1
,2
]}

Tanaka, Masao ^{[1
,2
]}

Majima, Yoshiyuki ^{[1
,2
]}

Jensen, Robert T. ^{[1
,2
]}

Hirata, Koichi ^{[1
,2
]}

Imamura, Masayuki ^{[1
,2
]}

Uemoto, Shinji ^{[1
,2
]}

机构：

[1] Fukuoka Sanno Hosp, Neuroendocrine Tumor Ctr, Sawara Ku, 3-6-45 Momochihama, Fukuoka 8140001, Japan

[2] Internal Univ Hlth & Welf, Grad Sch Med Sci, Dept Gastroenterol, Sawara Ku, 3-6-45 Momochihama, Fukuoka 8140001, Japan

来源：

JOURNAL OF GASTROENTEROLOGY | 2021年 / 56卷 / 11期

关键词：

Clinical practice guideline; Gastroenteropancreatic neuroendocrine neoplasm; Japanese Neuroendocrine Tumor Society; ZOLLINGER-ELLISON-SYNDROME; ATYPICAL ENDOSCOPIC FEATURES; ENETS CONSENSUS GUIDELINES; INSTITUTES-OF-HEALTH; PROGNOSTIC-FACTORS; JAPANESE PATIENTS; SERUM GASTRIN; TUMORS; MANAGEMENT; DISEASE;

D O I：

10.1007/s00535-021-01827-7

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Neuroendocrine neoplasms (NENs) are rare neoplasms that occur in various organs and present with diverse clinical manifestations. Pathological classification is important in the diagnosis of NENs. Treatment strategies must be selected according to the status of differentiation and malignancy by accurately determining whether the neoplasm is functioning or nonfunctioning, degree of disease progression, and presence of metastasis. The newly revised Clinical Practice Guidelines for Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs) comprises 5 chapters-diagnosis, pathology, surgical treatment, medical and multidisciplinary treatment, and multiple endocrine neoplasia type 1 (MEN1)/von Hippel-Lindau (VHL) disease-and includes 51 clinical questions and 19 columns. These guidelines aim to provide direction and practical clinical content for the management of GEP-NEN preferentially based on clinically useful reports. These revised guidelines also refer to the new concept of "neuroendocrine tumor" (NET) grade 3, which is based on the 2017 and 2019 WHO criteria; this includes health insurance coverage of somatostatin receptor scintigraphy for NEN, everolimus for lung and gastrointestinal NET, and lanreotide for GEP-NET. The guidelines also newly refer to the diagnosis, treatment, and surveillance of NEN associated with VHL disease and MEN1. The accuracy of these guidelines has been improved by examining and adopting new evidence obtained after the first edition was published.

引用

页码：1033 / 1044

页数：12

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