Ganglioside GM1 mimics: Lipophilic substituents improve affinity for cholera toxin

被引：17
|
作者：
Arosio, D [1 ]
Baretti, S [1 ]
Cattaldo, S [1 ]
Potenza, D [1 ]
Bernardi, A [1 ]
机构：
[1] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 21期
关键词：
D O I：
10.1016/j.bmcl.2003.07.007
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Ganglioside GM1 mimics including (R)-2-hydroxy-3-cyclohexylpropionic acid or (R)-2-hydroxy-3-phenylpropionic acid as replacements for NeuAc are stronger cholera toxin binders than the parent ligand 2, which includes (R)-2-hydroxy-propionic acid. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3831 / 3834
页数：4
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