Successful treatment of fibrosing cholestatic hepatitis with pegylated interferon, ribavirin and sofosbuvir after a combined kidney-liver transplantation

被引：20

作者：

Delabaudiere, Cyrielle ^{[1
]}

Lavayssiere, Laurence ^{[1
]}

Doerr, Gaelle ^{[1
]}

Muscari, Fabrice ^{[2
,3
]}

Danjoux, Marie ^{[4
]}

Sallusto, Federico ^{[5
]}

Peron, Jean Marie ^{[3
,6
]}

Bureau, Christophe ^{[3
,6
]}

Rostaing, Lionel ^{[1
,3
,7
]}

Izopet, Jacques ^{[3
,7
,8
]}

Kamar, Nassim ^{[1
,3
,7
]}

机构：

[1] CHU Rangueil, Dept Nephrol & Organ Transplantat, F-31059 Toulouse 9, France

[2] Univ Hosp Rangueil, Dept Surg & Liver Transplantat, Toulouse, France

[3] Univ Toulouse 3, F-31062 Toulouse, France

[4] CHU Purpan, Dept Pathol, Toulouse, France

[5] CHU Rangueil, Dept Urol & Kidney Transplantat, F-31059 Toulouse 9, France

[6] CHU Purpan, Dept Hepatol, Federat Digest, Toulouse, France

[7] CHU Purpan, IFR BMT, INSERM, U1043, Toulouse, France

[8] CHU Purpan, Virol Lab, Toulouse, France

来源：

TRANSPLANT INTERNATIONAL | 2015年 / 28卷 / 02期

关键词：

fibrosing cholestatic hepatitis; hepatitis C virus; kidney transplantation; liver transplantation; sofosbuvir; RECIPIENTS; THERAPY; PEGINTERFERON; INFECTION; ALPHA;

D O I：

10.1111/tri.12428

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Fibrosing cholestatic hepatitis (FCH) is a classical but rare and severe form of recurrent hepatitis C virus (HCV) after liver transplantation. Classical anti-HCV therapy, that is pegylated-interferon (peg-interferon) and ribavirin, has been shown to have limited efficacy in treating FCH. Herein, we report on the first case of successful use of peg-interferon, ribavirin, plus sofosbuvir to treat HCV-induced FCH in a combined liver-kidney transplant patient. Antiviral therapy was given for 24 weeks. HCV clearance occurred within 4 weeks after starting therapy and was maintained until 4 weeks after the end of therapy. Antiviral tolerance was good. We conclude that the use of sofosbuvir-based anti-HCV therapy can be successfully used to treat FCH after a liver or combined kidney-liver transplantation.

引用

页码：255 / 258

页数：4

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