The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site

被引：124

作者：

Li, Qing ^{[1
,2
]}

Qi, Jianxun ^{[1
]}

Zhang, Wei ^{[1
,3
]}

Vavricka, Christopher J. ^{[1
]}

Shi, Yi ^{[1
,3
]}

Wei, Jinhua ^{[1
,3
]}

Feng, Enguang ^{[4
]}

Shen, Jingshan ^{[4
]}

Chen, Jilong ^{[1
]}

Liu, Di ^{[1
,5
]}

He, Jianhua ^{[6
]}

Yan, Jinghua ^{[1
]}

Liu, Hong ^{[4
]}

Jiang, Hualiang ^{[4
]}

Teng, Maikun ^{[2
]}

Li, Xuebing ^{[1
]}

Gao, George F. ^{[1
,2
,3
,7
]}

机构：

[1] Chinese Acad Sci, CAS Key Lab Pathogen Microbiol & Immunol, Inst Microbiol, Beijing, Peoples R China

[2] Univ Sci & Technol China, Coll Life Sci, Hefei 230026, Peoples R China

[3] Chinese Acad Sci, Grad Univ, Beijing, Peoples R China

[4] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China

[5] Chinese Acad Sci, Network Informat Ctr, Inst Microbiol, Beijing, Peoples R China

[6] Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai, Peoples R China

[7] Chinese Acad Sci, Beijing Inst Life Sci, Beijing, Peoples R China

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2010年 / 17卷 / 10期

基金：

中国国家自然科学基金;

关键词：

ORIGIN INFLUENZA-VIRUS; A VIRUSES; HEMAGGLUTININ; INHIBITORS; DESIGN;

D O I：

10.1038/nsmb.1909

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Influenza A virus neuraminidase can be classified into groups 1 and 2 on the basis of its primary structure. The main structural feature of group 1 neuraminidase is an extra cavity in the active site, the 150-cavity. Here we present the crystal structure of neuraminidase from the 2009 pandemic H1N1 influenza strain. In contrast to other characterized N1 neuraminidases, which are all members of group 1, 2009 H1N1 neuraminidase does not have a 150-cavity.

引用

页码：1266 / 1268

页数：3

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