Inhibition of mTORC2 Upregulates PDGFRs Expression and Contributes to the Development of Pulmonary Hypertension

被引：0
|
作者：
Tang, H. [1 ]
Wu, K. [1 ]
Gu, Y. [1 ]
Wang, J. [1 ]
Makino, A. [2 ]
Yuan, J. X. [1 ]
机构：
[1] Univ Arizona, Dept Med, Tucson, AZ USA
[2] Univ Arizona, Dept Physiol, Tucson, AZ USA
来源：
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2018年 / 197卷
关键词：
D O I：
暂无
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
A2107
引用
收藏
页数：2
相关论文
共 50 条
  • [21] Mammalian Target of Rapamycin Complex 2 ( mTORC2) Coordinates Pulmonary Artery Smooth Muscle Cell Metabolism, Proliferation, and Survival in Pulmonary Arterial Hypertension
    Goncharov, Dmitry A.
    Kudryashova, Tatiana V.
    Ziai, Houman
    Ihida-Stansbury, Kaori
    DeLisser, Horace
    Krymskaya, Vera P.
    Tuder, Rubin M.
    Kawut, Steven M.
    Goncharova, Elena A.
    CIRCULATION, 2014, 129 (08) : 864 - 874
  • [22] Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins
    Schreiber, Katherine H.
    Ortiz, Denise
    Academia, Emmeline C.
    Anies, Arieanna C.
    Liao, Chen-Yu
    Kennedy, Brian K.
    AGING CELL, 2015, 14 (02): : 265 - 273
  • [23] mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
    Park, Tae Kwann
    Yang, Jin Young
    Madrakhimov, Sanjar
    Ohn, Young-Hoon
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2019, 60 (09)
  • [24] mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
    Yang, Jin Young
    Madrakhimov, Sanjar Batirovich
    Ahn, Dong Hyuck
    Chang, Hun Soo
    Jung, Sang Joon
    Nah, Seung Kwan
    Park, Ha Yan
    Park, Tae Kwann
    CELL COMMUNICATION AND SIGNALING, 2019, 17 (1)
  • [25] Rapamycin (RAPA) Induces Klotho Expression through mTORC2 Activation
    Tataranni, T.
    Colucci, G.
    Biondi, G.
    Mangino, M.
    Pertosa, G.
    Simone, S.
    Ditonno, P.
    Schena, F. P.
    Gesualdo, L.
    Grandaliano, G.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2011, 11 : 356 - 356
  • [26] mTORC2 controls T-cell receptor processing and surface expression during thymocyte development
    Werlen, Guy
    Chou, Po-Chien
    Oh, Won
    Wu, Chang-Chih
    Ruegg, Markus
    Hall, Michael
    Jacinto, Estela
    JOURNAL OF IMMUNOLOGY, 2012, 188
  • [27] mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
    Jin Young Yang
    Sanjar Batirovich Madrakhimov
    Dong Hyuck Ahn
    Hun Soo Chang
    Sang Joon Jung
    Seung Kwan Nah
    Ha Yan Park
    Tae Kwann Park
    Cell Communication and Signaling, 17
  • [28] Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to the development of pulmonary arterial hypertension
    Guo, Dongqing
    Gu, Junzhong
    Jiang, Hui
    Ahmed, Asif
    Zhang, Zhiren
    Gu, Yuchun
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2016, 91 : 179 - 187
  • [29] Selective inhibition of mTORC2 by disruption of mLST8 scaffolding function
    Kim, Laura C.
    Hwang, Yoonha
    Song, Wenqiang
    Cook, Rebecca S.
    Chen, Jin
    CANCER RESEARCH, 2019, 79 (13)
  • [30] Dual inhibition of mTORC1 and mTORC2 perturbs cytoskeletal organization and impairs endothelial cell elongation
    Tsuji-Tamura, Kiyomi
    Ogawa, Minetaro
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 497 (01) : 326 - 331
12345