Copper-catalyzed, oxidative sp2 C-H cyanation: facile synthesis of aromatic carbonitriles

被引：8

作者：

Liu, Jin-Qiang ^{[1
]}

Hao, Bao-Yu ^{[2
,3
]}

Zou, Hao ^{[2
]}

Zhang, Wei-Han ^{[2
]}

Chen, Xin-Zhi ^{[3
]}

机构：

[1] Luoyang Normal Univ, Coll Chem & Chem Engn, Luoyang 471022, Peoples R China

[2] Hutchison MediPharma Ltd, Shanghai 201203, Peoples R China

[3] Zhejiang Univ, Dept Chem & Biol Engn, Hangzhou 310027, Zhejiang, Peoples R China

来源：

ARKIVOC | 2014年

基金：

高等学校博士学科点专项科研基金;

关键词：

C-H activation; cyanation; copper catalyzed; aryl carbonitriles; NITRILES; CYANIDE; N; N-DIMETHYLFORMAMIDE; HETEROARENES; ALCOHOLS; INDOLES;

D O I：

10.3998/ark.5550190.p008.682

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cu(OAc)(2)-catalyzed regioselective oxidative C-H cyanation of two different types of aromatics was described, providing facile access to functionalized heterocycles in good yields. Control experiments suggest the copper chelation-assisted oxidative C-H activation mechanism.

引用

页码：72 / 93

页数：22

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