Solid-phase synthesis of 3H-quinazolin-4-ones based on an aza Wittig-mediated annulation strategy

被引：1

作者：

Villalgordo, JM ^{[1
]}

Obrecht, D ^{[1
]}

Chucholowsky, A ^{[1
]}

机构：

[1] F Hoffmann La Roche AG, Pharma Res, CH-4002 Basel, Switzerland

来源：

SYNLETT | 1998年 / 12期

关键词：

solid-phase synthesis; polymer-bound carbodiimides; quinazolinone library; aza Wittig-mediated cyclization; multidirectional cleavage;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aza Wittig-mediated annulation provides a highly efficient and straightforward strategy for the parallel synthesis of 3H-quinazolin-4-ones on solid support. The products were recovered in good yields and exhibited excellent purities.

引用

页码：1405 / 1407

页数：3

共 50 条

[31] T3P catalyzed one pot three-component synthesis of 2,3-disubstituted 3H-quinazolin-4-ones
Raghavendra, Goravanahalli M.
Kumar, Chottanahalli S. Pavan
Suresha, Gejjalagere P.
Rangappa, Kanchugarakoppal S.
Mantelingu, Kempegowda
CHINESE CHEMICAL LETTERS, 2015, 26 (08) : 963 - 968
[32] Synthesis of 2, 3-Disubstituted-Quinazolin-4-(3H)-ones
Patil, D. A.
Patil, P. O.
Patil, G. B.
Surana, S. J.
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2011, 11 (08) : 633 - 641
[33] Solid-phase combinatorial synthesis of 4-hydroxyquinolin-2(1H)-ones
Sim, MM
Lee, CL
Ganesan, A
TETRAHEDRON LETTERS, 1998, 39 (35) : 6399 - 6402
[34] SYNTHESIS OF BENZOXAZOLYLTHIOMETHYL AND BENZTHIAZOLYLTHIOMETHYL QUINAZOLIN-4(3H)-ONES
Rafeeq, Mohammad
Reddy, Chittireddy Venkata Ramana
Dubey, Pramod Kumar
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2015, 190 (11) : 1857 - 1864
[35] Solid-phase synthesis of 1,2,3,4-tetrahydro-2-pyridones via aza-annulation of enamines
Paulvannan, K
Chen, T
JOURNAL OF ORGANIC CHEMISTRY, 2000, 65 (19): : 6160 - 6166
[36] Synthesis of novel 3-(alkylcarbamoyl)-2-aryl-11,2-dihydro-6,7(methylenedioxy)-3H-quinazolin-4-ones as anticonvulsant agents
Micale, N
Postorino, G
Grasso, S
Zappalà, M
Zuccalà, G
Ferreri, G
De Sarro, G
CHEMISTRY & BIODIVERSITY, 2006, 3 (03) : 304 - 311
[37] Synthesis of 1H-pyrazolo[3,4-d]pyrimidines via solid-phase Aza-Wittig/electrocyclic ring closure reaction
Liao, Subo
Xing, Li
Hamper, Bruce
TETRAHEDRON LETTERS, 2013, 54 (50) : 6855 - 6857
[38] Solid-phase parallel synthesis of 2-aminoimidazolidin-4-ones
Yu, YP
Ostresh, JM
Houghten, RA
TETRAHEDRON, 2002, 58 (17) : 3349 - 3353
[39] NHC-Catalyzed Benzylic Csp3-H Bond Activation of Alkylarenes and N-Benzylamines for the Synthesis of 3H-Quinazolin-4-ones: Experimental and Theoretical Study
Alanthadka, Anitha
Devi, E. Sankari
Nagarajan, Subbiah
Sridharan, Vellaisamy
Suvitha, Ambigapathy
Maheswari, C. Uma
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2016, 2016 (28) : 4872 - 4880
[40] Solid-phase one step synthesis of 4H,4′-exomethylene-bis[quinazolin-2-enols]
Ganai, BA
Koul, S
Razdan, TK
Andotra, CS
SYNTHETIC COMMUNICATIONS, 2004, 34 (10) : 1819 - 1823

← 1 2 3 4 5 →