This paper studies on targeted poverty alleviation (TPA) in China rural region from the perspectives of government operation in Multi-departments of China. Through defining poverty, comparing and contrasting absolute poverty and relative poverty, based on multidimensional poverty measurement theory, the paper argues poverty line in China. From the achievements targeted poverty alleviation produced, the article proposes some suggestions improving the government performance on TPA. Based on the multidimensional poverty measurement and poverty line in China, this paper illustrates that poverty alleviation has benefited from government multi-sectorial participation. Meanwhile, the paper shows some TPA practical experiences from government sectors and presents actions, including international cooperation, knowledge exchange and the usage of the Internet and big data in building TPA platform in poverty alleviation, which benefited China, Asia and the world. Conclusively, the article points out that it is crucial for the government to update poverty alleviation.