Relation between markers of inflammation and estradiol in older men

被引：1
|
作者：
Barud, Wojciech [2 ]
Palusinski, Robert [3 ]
Beltowski, Jerzy [4 ]
Wojcicka, Grazyna [4 ]
Myslinski, Wojciech [2 ]
Grzybowski, Andrzej [1 ]
Makaruk, Boguslaw [2 ]
Mieczkowska, Jolanta [2 ]
Mosiewicz, Jerzy [2 ]
机构：
[1] Poznan City Hosp, Dept Ophthalmol, PL-61285 Poznan, Poland
[2] Med Univ Lublin, Dept Internal Med, Lublin, Poland
[3] John H Stroger Jr Hosp Cook Cty, Chicago, IL USA
[4] Med Univ Lublin, Dept Pathophysiol, Lublin, Poland
来源：
MEDICAL SCIENCE MONITOR | 2010年 / 16卷 / 12期
关键词：
atherosclerosis; C-reactive protein; fibrinogen; sex hormones; C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; MIDDLE-AGED MEN; CARDIOVASCULAR-DISEASE; TRANSDERMAL ESTRADIOL; POSTMENOPAUSAL WOMEN; PROSTATE-CANCER; ARTERY-DISEASE; SEX-HORMONES; RISK-FACTOR;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background: Inflammation plays a key role in the development of atherosclerosis. Studies in women receiving estrogens show their proinflammatory effects. This study sought to determine relation between sex hormones and 2 inflammation markers: C-reactive protein and fibrinogen. Material/Methods: One hundred men of at least age 50 years were enrolled in the study. Plasma levels of total testosterone, estradiol, sex hormone binding globulin, high-sensitivity C-reactive protein, and fibrinogen were measured. Free estradiol and free testosterone were calculated. Results: Estradiol and free estradiol levels were positively correlated with C-reactive protein and fibrinogen. In a subgroup analysis, this association persisted only in patients with stable coronary artery disease. No significant correlations were found between testosterone, free testosterone, sex hormone binding globulin, and markers of inflammation. Conclusions: This study suggests that estradiol may have proinflammatory effects in older men with coronary artery disease.
引用
收藏
页码：CR593 / CR597
页数：5
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